Yes she can get pregnant as long as she has completed her therapy and is several months out ideally. The therapy should have no effect on her ability to stay pregnant. As far as breastfeeding, that would depend on the amount of breast tissue she has available and would be recommended that she tries.
It would effect him only in his ability to have sex and ejaculate. If that is not a problem for him, then I do not suspect there would be a problem in achieving a pregnancy. There may be other genetic components that I am not aware of for your husband and can be questioned during a preconception counseling or fertility appointment. But as long as both of you are under the age of 30, then it would be fair to give it a year of attempting a pregnancy on your own. Open neural tube defect are usually multi-factorial and may not be reoccurring.
Best wishes and congratulations on starting your family.