Here is the write up:
PIN begins to appear in the prostates of some men as early as their 20s. Almost half of all men have PIN by the time they reach 50. High-grade PIN is considered a pre-cancer of the prostate because it may turn into prostate cancer over time.
Low-grade PIN in general should not be on a biopsy report, as it has no significance. If I have high-grade PIN, does that mean it will turn into prostate cancer?
No. In most cases, high-grade PIN will not turn into cancer over the next several years. Still, the risk of getting cancer later is higher if high-grade PIN is found in more than one biopsy core. What does it mean if the report says that only one of my biopsy samples (cores) shows high-grade PIN, but it does not mention carcinoma (cancer)?
It means there is no cancer in this biopsy sample. In most cases, even a repeat biopsy will not show cancer. Do I need a repeat prostate biopsy over the next year or several years after a diagnosis of high-grade PIN?
In most cases, the chance of finding cancer is low, so a repeat biopsy done soon after the diagnosis of high-grade PIN is not useful. However, some patients do have a higher risk, such as men with multiple cores showing high-grade PIN. Discuss if and when you have a repeat biopsy with your doctor.