Finding the antioxidant/oxidant balance is important
In recent years, although improvements have been made in the care of individuals with CF, this condition remains the most common fatal genetic disorder in the United States. Associations between CF lung disease progression and oxidative stress have been made, presenting evidence that CFTR expression and function are modified by oxidative stress and that its loss may result in a poor response to oxidants in the body. In addition, airway infection and inflammatory processes in CF are potential sources of oxidants that can affect normal breathing levels and contribute to changes associated with loss of lung function. All of these irregularities in the oxidant and antioxidant balance raise questions that can only be answered through careful assessment in clinical trials. In turn, the answers could potentially have significant effects on therapeutic interventions for individuals living with CF.
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