Asthma Medicine May Hold the Key for Parkinson's Disease
Asthma, which causes wheezing, breathlessness, chest tightness, and coughing, is a lifelong disease. Asthma affects 1 in every 12 people in the United States, and doctors say it’s just climbing. The most effective way to combat asthma is with an asthma pump, to be used when a patient feels their asthma worsening. Some of these inhalers include the medicine Salbutamol, which is a drug that widens the airway passages in patients with asthma.
Asthma is a lifelong disease that causes wheezing, coughing and chest tightness. Using asthma pump, asthma can be combated. Salbutamol may be present in some of these inhalers. In Parkinson’s disease the neurons tend to die. In America one million people are affected and this disease is incurable. In 1984 Muhammad Ali was diagnosed in 1984 and then Michael J Fox was diagnosed whose career took a sharp turn.
It was noted during a study that likelihood of the Parkinson’s disease is less when salbutamol is taken in highest dose. In the medical community this was a gigantic deal. This disease is pretty evasive. In the brain cells the protein a-synuclein builds up and this may even kill the cells. To speed up the disappearance of this protein scientists have been tirelessly making efforts. They tried to prevent the build up of the protein.
In the lab the scientists grew human nerve cells. They tried to see the impact on the output of this dangerous protein by using various types of vitamins, medicines, other molecules and dietary supplements. Some interesting things they noted were that the proteins ability to cut down was reduced by the drugs. One of this drug was salbutamol. But they did this particular action by stimulating b2-adrenoreceptor. This drug is very common. Hence scientists decided of seeing whether in people using salbutamol for asthma has lower diagnosis. For this they needed a larger database. This was found in Norway. This disease was found to be rare in Norway it was noted that in 0.1 percent people Parkinson’s disease developed since they were not using salbutamol. However the 0.4 percent of people who took the drug developed the disease. Further considering the other factors it was noted that once in their lifetime those who had taken salbutamol has 33.3 percent less chances of developing the disease.
The chance of developing the disease was determined by the amount of sabutamol that was taken. They conducted a study from which they concluded that between the years 2004 and 2007 those who took the drug in highest dose, in the next seven years had 50 percent less chances of developing Parkinson’s disease whereas those who took in lowest dose, the chances of developing the disease slightly lowered.
The results are fascinating. But a neurologist Anthony Lang feels that these findings are sceptical even though he is happy about the findings. The study shows that the impact of salbutamol on Parkinson’s disease is sceptical. If the findings are true then not a single patient with Parkinson’s disease will have asthma but this is not the case. In order to help the patient with the disease, the route that is harnessed to obtain the results, the researchers are not totally positive about it. Many feel that the best way to find out would be doing clinical trials of salbutamol or similar drugs. For patients with chronic and incurable disease, medical experiments or observation done in clinical trials are especially helpful. Disease with high mortality rate has been treated using clinical trials.
Till now no drugs have been found that can relax the airways and enter the brain effectively. Such drugs are yet to be developed. Also 16 recent clinical trials were conducted for treatment of Parkinson’s disease and all have failed. Due to this failure he is anxious about putting clinical trials into actions. The next logical step would be to develop a medicine that can target the dangerous protein and at the same time effectively enter the brain too. Hopefully in less than a few years scientists are able to find a way.