Causes of Asthma
Asthma is a chronic airway inflammation with cellular infiltration by T helper 2 cells, lymphocytes, oenophiles and mast cells with cytokine production. Airway obstruction occurs due to inflammatory cell infiltration, mucus hyper-secretion with mucus plug formation and smooth muscle contraction.
What are the causes of bronchial asthma?
• Atopy: Atopy is a predisposition toward developing certain allergic hypersensitivity reactions.
• Genetic factors: A hereditary component to asthma and atopy is well established.
• Hygiene: Asthma may be a by-product of modern cleanliness. Early life exposure to bacterial endotoxins switch off the allergic response. When this exposure is lost, the likelihood of developing allergic diseases such as asthma increases considerably.
• Other predisposing factors: Exercise, obesity, emotional stress and some drugs, such as aspirin, NSAIDs hypersensitivity or β-blockers.