Drug warnings to consider
There are numerous warnings and precautions for patients who take or are considering taking ADCETRIS, including a boxed warning of progressive multifocal leukoencephalopathy (PML). PML is a rare virus which inflames the white matter of the brain resulting in death. ADCETRIS is contraindicated in patients with concomitant bleomycin because of pulmonary toxicity. Other warning and precautions include: peripheral neuropathy which usually occurs over time, infusion reactions and possible anaphylaxis, hematologic toxicities like severe neutropenia, thrombocytopenia or anemia may occur, infections like pneumonia, bacteremia and sepsis may occur, tumor lysis syndrome, increased risk of toxicity in patients with severe renal impairment, increased risk of toxicity in patients with severe hepatic impairment, hepatotoxicity, pulmonary toxicity, dermatologic reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) which could result in death, gastrointestinal (GI) complications and Embryo-fetal toxicity.