How This Protein Can Inhibit Multiple Sclerosis Inflammation

The effects of the study were excellent. IL-12p35 successfully demonstrated anti-inflammatory effects of a similar magnitude and effectiveness of the full IL-35 protein. Scientists also observed that the subunit of IL-35 protein promoted the growth of b-cells that had a positive, counter effect to negative immune system responses. This not only stopped the symptoms of inflammation in the mice with uveitis, but reversed them altogether.

This exciting discovery marked one of the first times that an autoimmune response was stopped without applying medication or therapy designed to limit or reduce immune cell count in the bloodstream. The discovery was so impactful that senior author of the study, Dr. Charles Egwuagu, Chief of the Molecular Immunology section at the National Eye Institute’s Laboratory of Immunology said that “these individual subunits may form a new generation of biologics that can be used to treat autoimmune and neurodegenerative diseases.”