New Research Evaluates Evolution of Crohn's Symptoms Over Time
Patients with Crohn's disease often experience changing degrees of intensity with their symptoms over time. Physicians need to be able to develop accurate Crohn's disease phenotypes to administer the best treatment possible. A study by de Barros KSC and colleagues was conducted to find out the long-term evolution of symptoms in patients based on various factors, including disease phenotypes.
The researchers collected data from 179 patients with Crohn's disease. The researchers then used the Montreal classification and the Kaplan-Meier method to determine the approximate cumulative probability of complication development and surgery. The team then applied the Poisson regression method to extract a multivariate analysis. This research study was approved by the Local Institutional Review Board.
Over time, Crohn’s patients will experience a variety of changes in the degree of their symptoms as well as their intensity. A study was conducted to identify the long-term evolution of the symptoms in Crohn’s patients based on several factors, including disease phenotypes. The data in this research study revealed that the clinical behavior was altered in one third of the participants, wherein a change in the structuring pattern was a frequently observed complication. Also, other factors such as the exact location of the disease, use of immunosuppressants, hospitalization, and abdominal surgery were all known be linked with an unfavorable clinical evolution.
Research showed that individuals suffering from ulcerative colitis tested positive for the presence of nicotine, which is known to have detrimental effects on those with Crohn’s disease as well. Those who were or are active smokers were at a higher risk of developing this disease than those who didn’t smoke at all. Individuals who were secondhand smokers or passive smokers were also at a high risk of getting Crohn’s disease. According to the Health Institute, a link has been found between smoking and the progression or worsening of symptoms. Smoking can lead to a defect in the defense mechanism of the intestines, thereby inducing alterations of the immune system which in turn can cause an increase in inflammation in the body or reduce the blood flow to the intestines. Smoking raises the risk of cancer as well, mostly of the mouth, stomach, esophagus, liver, rectum, and colon. It is also said to be a triggering factor for various medical disorders as well as issues concerning the digestive system, which can include liver disease, heartburn, peptic ulcers, and gastroesophageal reflux disease. Apart from these, smoking also leads to a higher risk of colon polyps, gallstones, and Crohn’s disease.
Per another research study conducted, it was found that individuals who stay in urban households and in a northern climate are also at a higher risk of getting Crohn’s disease. Two separate studies were carried out to evaluate the various environmental factors that can possibly contribute to the development of Crohn’s. The researchers identified that women who resided in warm climates had a decreased risk of getting IBD compared to those who resided in colder regions. This finding also seemed to increase for women who were younger than 30 years of age. Both of these research studies include a list of extensive information.
Considering all the risk factors, such as those who smoke, women who reside in urban communities in northern regions are considered to be at a higher risk of developing IBD, which can also include Crohn’s disease, than women who do not smoke at all or who live in a rural household in a southern region.