New Study Attempts to Interrupt Parkinson's Disease
Studies and efforts to stop chronic neurodegenerative diseases never stop. As new discoveries are used to diagnose patients, the level of severity is also a main target of new research. Nevertheless, there are also many researches on how to slow Parkinson’s progression.
According to a study published in the journal Science, a group of scientists from Northwestern University were able to identify a specific toxic cascade that causes neuronal degeneration in people suffering from Parkinson’s. What made the difference between this research and the rest is that the group of Northwestern scientist found a way to interrupt said toxic cascade.
The same study showed that an antioxidant can help a lot when looking to pause the evolution of the disease when implemented during early stages of the condition. Antioxidants have the ability to break the degenerative cycle triggered by Parkinson’s disease and it also helps improving neuronal functioning.
These results are a breath of fresh air for people suffering from the condition since they are a starting point for the development of new therapies. The importance of this research along with the effects they have on human neurons are critically important for new solutions.
From north-western university a group of researchers identifiedin people suffering from Parkinson’s disease a group of toxic cascade. Further they were even able to interrupt that toxic cascade. Also the same study showed that antioxidant can help a lot when implemented during early stages of the condition. The degenerative cycle of Parkinson’s disease can be broken down by antioxidants. Also they can help to improve the neuronal function. For people suffering from this condition, these results gave abreath of fresh air since for development of new therapies they are at least a starting point.
This study was started in the lab of doctor Dimitri Krianc situated in the state of Massachusetts. The study took place six years ago and during the first two years, installation of Harvard Medical School has been used. At Feinberg the study was completed. During the last four years the activities related to the study took place there. For this study Dimitri Krianc was the senior author and the person in charge. At the Aaron Montgomery Ward, he is also a professor. Lena Burbulla was also the author of this study and was a colleague. They both took into account that death was caused by this neurodegenerative disease due to intervention of toxins. Thus with antioxidants they developed treatments. Their study has proved to delay the process or even stop the process. In order to determine whether antioxidants can really stop the degenerative process, they also used human neurons in their study which was another relevant fact. For effective treatment, this study is an excellent way to start a new research and through this a definite cure can be developed.
Parkinson’sdisease is the second most common neurodegenerative disease. In this disease the neurons located in the part of the brain that contains dopamine and controls motor actions die. Aspeople age they tend to lose dopamine neurons. However in case of Parkinson’s the loss of dopamine neurons is too large that the ones that are not destroyed cannot compensate for it.
It is important to understand why death of dopamine neurons takes place. Then only proper treatment for the condition can be determined. According to previous studies, mitochondria and lysosomes cause cell death. The cascade of mitochondrial and lysosomal dysfunction was identified by Krianc and his team. Through accumulation of a protein called alpha-synuclein and oxidized dopamine this was possible. They saw that the activity of an enzyme called lysosomal glucocerebrosidase caused accumulation of oxidized dopamine. Thus the overall lysosomal function would get weakened. This would cause the neurons to get destroyed.
The lysosomes are interfered with oxidized dopamine. By increasing mitochondrial oxidant stress, the dopamine would also damage neurons mitochondria causing increase in the level of oxidized dopamine. This would create a cyclic state. According to Kriance, two critical pathways in the development of the disease are the mitochondrial and lysosomal pathways. Once the team was aware about the toxic cascade of neurone they were able to find ways to interrupt it. By lowering the oxidized dopamine, improving the mitochondrial oxidant stress, was the key strategy in all the experiments according to Kriance. They did this by using antioxidants. According to him, the downstream toxic effects could be attenuated and even completely prevented in human dopaminergic neurons by this approach.