Difference in cell behaviors
Three days later, Lutz and fellow colleagues found that Th1 cells were getting into and damaging the myelin sheath and the neurons; however, these cells did not pass through the tight junctions, as did the Th17 cells. Instead, the Th1 cells reached the myelin sheath and the neurons by going through specialized cell membrane structures known as caveolae. Caveolae are small cave-like structures that are found of the surface of several types of cells. They help the transmission of various cells, molecules, and other materials into or through cells.