Effectiveness in mice
Michael Helmrath, a pediatric surgeon and director of the Surgical Research program led a team of researchers from the Division of Surgery to determine the manner in which gastrointestinal tract tissues behave inside of a living organism. The team also wanted to determine the possibility of therapeutic applications and potential in the future.
The team of researchers took the colonic organoids that were engineered from tissues and transplanted the organoids into mouse models. The immunocompromised mouse models had the colonic organoids transplanted into their kidney capsules. For the duration of about six or ten weeks, the mouse models with their transplanted colonic organoids were observed and analyzed. The authors of the study inspected the mouse models closely for any sign of posterior region enteroendocrine cells. These cells make the hormones that can be found in naturally developing human colons.