According to a long-term research project known as the Framingham Study, although it has not been reflected in male participants, there has been a significant association between the thyroid stimulating hormone and the risk of women in developing Alzheimer’s disease. Neuropsychological tests allowed the participants of the Framingham Study to compare TSH levels in association with irreversible neurological problems like Alzheimer’s. A hypothesis was made in this study that an Amyloid Precursor Protein regulator, which is a gene, may take part in the responsibility for developing Alzheimer’s. Then the TSH levels could create an impact on the inducing of Alzheimer’s in a person. TSH levels, that are exceptionally high or low, can cause improper regulation of APP that could lead to this neurological problem. However, it wasn’t clear whether the levels of TSH are causing Alzheimer’s or if Alzheimer’s is the only reason for changing the levels of TSH in a person.