Healthy Living

When Does Arthralgia Progress to Rheumatoid Arthritis?

Conclusion: The antibodies accurately predict risk

Researchers posited that additional biomarkers are needed for optimal prediction of risk.

Positive predictive values of those additional biomarkers for the development of RA within 2 years were:

  • 38% for ACPA-negative/RF-positive patients
  • 50% for ACPA-positive/RF-negative participants

As pre-noted, those testing positive for ACPA conferred the highest risk for the development of Rheumatoid arthritis and had an additive value with a positive rheumatoid factor.

The study’s conclusion was the presence of these autoantibodies “accurately predicts a person's risk for progression from clinically suspect arthralgia (CSA) to rheumatoid arthritis (RA).”