Does Lupus cause kidney infection? Not exactly. But the drugs used in the treatment of the disease makes you more likely to get an infection of any type. Lupus makes your body turn against its organs and tissues. Lupus nephritis, for example, causes swelling or scarring to the small blood vessels that are responsible for filtering blood waste in the kidney. It makes them unable to remove waste from your blood as well as controlling the amount of fluid in the body. Because of abnormal wastes building in the blood, you develop swelling called edema. The result is that you have extra fluid that the kidney cannot get rid of. Therefore, you will have swelling in your body parts such as your legs, ankles, and around your eyes.