Results are consistent, and future studies look promising
Dr. Wei concludes his comments on the study: "One of the key challenges in this study was how to generate high-dimensional data from rare cell types while preserving the integrity of the tissue biology. Our analyses of joint inflammation are highly consistent across multiple independent analytic methods, including histology, flow cytometry, mass cytometry, and transcriptomics. Our next study will include more RA patients and longitudinal analysis of treatment response. The goal is to relate clinical course and treatment response with specific abnormal cell populations defined by mass cytometry and transcriptomics of the tissue and blood, and ultimately, to develop and test new treatment approaches."