The process of the new study
Upon modifying the retinal imaging trial, the researchers took flat mounts and cross sections from 23 deceased patients with AD and 14 controls, analyzing cellular layer, distribution, and structure of amyloid protein deposits. They also included 16 patients with AD who drank a liquid solution that included curcumin. Curcumin is a natural component of the spice turmeric and in the study; it was used to trigger the amyloid plaque in the retina by lighting it up. The study revealed an increased amount of amyloid-beta deposits and significant neuronal loss in patients with AD, in comparison to those without the condition. What’s more, the researchers observed AD pathologies and found that the retinal deposits were linked to the blood vessels in the peripheral regions of the three layers of the retina. They conducted further calculations using system, called the retinal amyloid index (RAI), which measured the amount of curcumin in each patient’s system.