Why treatment guidelines are lacking
Similarly, guidelines on treatment are speculative at best. Physicians recognize that chemotherapy can be effective, but the specific course of care isn’t established. It’s been difficult to find medications that will cross the blood-brain barrier and blood-nerve barrier, aspects of treat that are necessary to treat NL. Even treatments that are initially effective at treating NL tend to still have poor long-term outcomes. Despite its low prevalence, clinical trials examining more effective methods of standardized treatment for NL would be very useful for the lymphoma community. But, due to its rarity, this is unlikely to happen in the near future. Individual case studies, such as those previously mentioned, are currently the best method to review treatment options for NL.