1 What is Abbokinase?

Brand: Abbokinase, Kinlytic

Generic: Urokinase

Abbokinase is an enzyme which functions in dissolving clots in blood vessels as well as in the lungs. It is a strict prescription medication, common in use in the emergency department in hospitals of different countries.

Its use in the United States has ended in October 2010 and it is replaced by much better medications.

It is available in the form of powder for a solution which is then inserted directly into the vein.

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2 What to Know Before Using

Before starting Abbokinase, it is important for patient and doctor to hold a detailed session to check all the prerequisites. 

It is important that the patient discusses any doubts or queries with the doctor so that this drug can be used with much more understanding. The doctor should also inform all the effects and interactions and take an informed consent from the patient.

Detailed history of a patient is extremely important prior to any medical therapy and in this case, it is important to do it very quickly as the patient is usually in an emergency condition.

Allergies or any history of allergy to any drug, food, preservatives, dyes or animal products, history of drug usage, past medical or surgical procedure should also be kept in the record to predict any drug interaction.

Physical examination should be done before starting Abbokinase so that any physiological or pathological condition by which this drug may interfere may be ruled out.

Age-specific assessment is necessarily important to have a safety profile. Its safety has not been determined in children and elderly due to lack of enough studies, however, it is considered safe enough for use in them.

There is also not enough evidence to rule out its harm if used in pregnant or breastfeeding mothers.

Drug interactions may occur as a result of the use of certain medications together. It is important to have a thorough knowledge beforehand to predict such effects and to prevent them.

For this purpose, it is important that the patient gives a detailed history of any drug use. Use of this drug with any other anti-clotting or anti-platelet agent is contraindicated as it may lead to severe bleeding. Several foods, alcohol, and tobacco may be associated with drug interactions and the patient should find out about these from their health care provider.

Other medical conditions, like blood vessel problem, bleeding problem, brain disease, stroke, recent surgery of brain, spine or any major surgery, hypertension, recent trauma, clotting problems, heart disease, diabetic eye problems, liver disease, kidney disease, high cholesterol or any recent infection should be informed to the physician. The drugs taken for these conditions may interfere with working of Urokinase.

3 Proper Usage

To use Abbokinase properly, you must follow all instructions given by your doctor. It is available for intravenous use only. It is injected into the vein by a trained health care professional.

Good hygiene and proper technique may eliminate the chances of any local effect on the site of injections.

4 Precautions to Take

Abbokinase is an enzyme to dissolve blood clots. It is important to follow some precautions to maximize its effect and minimize the side effects.

  • Patient should remain on bed rest until the doctor declares the patient as fit.
  • Slight bleeding may occur which is harmless. If there is severe bleeding, consult your doctor about it.
  • Check for any bleeding or oozing from the site of injection or any other body site.
  • Stool and urine should be observed to see any blood in these.
  • Consult the doctor if any serious problem is suspected.
  • Storage of drug should be in a dry environment at room temperature. Keep it away from the reach of children.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Abbokinase. Undesirable effects are a drawback of any allopathic medication ever used but one has to consider the benefits of medications over side effects prior to usage of the drug.

Slight bleeding may occur as an effect of urokinase, but if it becomes severe bleeding, consult your doctor.

Bleeding gums, blood in sputum, difficulty breathing and swallowing, dizziness, headache, increased menstrual flow, nosebleeds, paralysis, prolonged bleeding from cuts, tarry stools, red or dark brown urine are common side effects.

Rarely, fast heartbeat, hives or welts, itching skin, puffiness of the eyelids, face and tongue may occur.

It is necessary to be on bed rest while being on this medication and consult your doctor about any side effect faced.

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