1 What is Accuretic?

Brand: Accuretic

Generic: Quinapril + Hydrochlorothiazide

Accuretic is a drug used for the treatment of hypertension. This product contains quinapril and hydrochlorothiazide. Quinapril is an angiotensin converting enzyme inhibitor while hydrochlorothiazide is a thiazide type of diuretic.

Accuretic is available in tablets of three different strengths:

  • 10/12.5 tablets: pink, scored elliptical, biconvex, film-coated tablets. Each tablet contains 10 mg of quinapril and 12.5 mg of hydrochlorothiazide.
  • 20/12.5 tablets: pink, scored triangular, film-coated tablets. Each tablet contains 20 mg of quinapril and 12.5 mg of hydrochlorothiazide.
  • 20/25 tablets: pink, round, biconvex, film-coated tablets. Each tablet contains 20 mg of quinapril and 25 mg of hydrochlorothiazide.


On doctor’s prescription. Avoid taking this drug within 4 hours of bedtime to avoid frequent urination at night. If you have any questions, ask your health care provider.

Drink plenty of liquids along with this medication to prevent dehydration. Do not take other medications or supplements without consulting your doctor first.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Accuretic may interact with the following medications:

  • Dofetilide
  • Aliskiren
  • Cisapride
  • Drugs affecting the bone marrow such as azathioprine
  • Drugs that can increase dizziness such as phenobarbital
  • Narcotic pain relievers such as codeine
  • Diazoxide
  • Lithium
  • Nonsteroidal anti-inflammatory drugs such as celecoxib, ibuprofen, or indomethacin
  • Probenecid
  • Potassium supplements
  • Salt substitutes
  • Drospirenone
  • Amphotericin B
  • Corticotropin
  • Corticosteroids including prednisone
  • Other diuretics such as amiloride, furosemide, triamterene
  • Drugs whose removal from the body is affected by the acid level of urine such as amphetamine, methenamine, and quinidine
  • Gold injections
  • Tetracycline antibiotics
  • Quinolone antibiotics such as ciprofloxacin, levofloxacin
  • Bisphosphonates such as risedronate
  • Cholestyramine and colestipol

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before using this drug, tell your health care provider if you have any of the following:

  • Allergy to either Quinapril or Hydrochlorothiazide
  • Allergy to other ACE inhibitors such captopril, lisinopril
  • Allergy to other thiazides such as chlorothiazide
  • Allergy after exposure to certain membranes used for blood filtering
  • Urinary problems
  • Swelling of the face and extremities
  • Kidney problems
  • Liver disease
  • Gout
  • Untreated salt/mineral imbalance
  • Dehydration
  • High levels of fats in the blood (high cholesterol/triglycerides)
  • Collagen vascular disease such as lupus or scleroderma
  • Recent nerve surgery
  • Schedule for surgery
  • Diabetes
  • Pregnancy or lactation