Generic: Estrogen And Progestin Combination (Ovarian Hormone Therapy) (Oral Route)
Activella (Estrogen And Progestin Combination) is used in the treatment of conditions which occur due to deficiency of these hormones being prepared in the body naturally.
Such condition naturally occurs after menopause when female ovaries cease the production of these hormones. This combination of hormones is also effective in preventing osteoporosis in older women.
These hormones are produced in the body and maintain the normal sexual development of females and are also responsible for regulation of menstrual in them. This combination drug is a prescription drug which is available only in the form of tablet.
2 What to know before using
Before using Activella, you must know all about the risks and complications associated with it.
The patient is the authoritative figure when it comes to any medical procedure or any drug therapy. It is important for the patient to know all the details about the drug and then start using it. Doctor also has a duty to bring out answers from the patient which play important role in treatment like history, any allergy or any medical condition the patient has. For this purpose, it is important to have a detailed session between patient and the physician before starting this drug to sort out all the details.
Detailed history of a patient is extremely important prior to any medical therapy and in this case it is more likely that a drug be started after it.
Allergies or any history of allergy to any drug, food, preservatives, dyes or animal products; history of drug usage, past medical or surgical procedure should also be kept in record to predict any drug interaction.
Physical examination should be done before starting this drug so that any physiological or pathological condition by which this drug may interfere may be ruled out.
Age specific analysis is vital to have information about side effects of different age groups. Enough studies are not available regarding its use in elderly population. It is not recommended for use in pregnancy or just after pregnancy. Moreover, it is also contradicted in nursing mothers as these hormones can pass through breast milk and cause hormonal imbalance.
Drug interactions are the effects on the therapy or the condition for which the drug is used by other drugs used concomitantly. It is necessary that no drug be started without consulting a physician as other drug may cause alteration in the effect of drug or its removal from the body.
There are certain drugs which are strictly contraindicated to be used with this hormone combination, including:
Boceprevir, Dasabuvir, Ombitasvir, Paritaprevir, Ritonavir and Tranexamic Acid.
However, there are some drugs which when used with this combination may increase the interactions. Hence, the physician changes the dose of either of these drugs to accommodate.
These drugs include:
Anagrelide, Bupropion, Carbamazepine, Ceritinib, Clozapine, Crizotinib, Dabrafenib, Darunavir, Donepezil, Eliglustat, Fentanyl, Idelalisib, Isotretinoin, Lumacaftor, Nilotinib, Paclitaxel, Piperaquine, Pirfenidone, Pixantrone, Sugammadex, Theophylline, Tizanidine, Topotecan and Uliprista. Patient should also be counselled about effects of alcohol and tobacco on the patient as these may cause severe interactions.
Medical conditions, other than the condition for which this drug is used, may also affect working of the drug and cause harm. It is important for the patient to give detailed history, and important for the doctor to derive such details from the patient to avoid such circumstances.
The conditions which may interact with this drug include:
To use Activella properly, you must follow all instructions given by your doctor.
It is a prescription medication available only in the form of tablet for oral use.
It is important for the doctor to devise a consultation chart for the patient to keep the progress in check.
It is important to read the drug manual which accompanies the medication for tips regarding its use.
4 Precautions to take
Before using Activella, there are some precautions you must take.
Precautions are the part and parcel of any treatment and patient must adhere to these to improve the outcome. It is the duty of the doctor or any medical care provider to make the patient aware about these tips as an aid to the therapy.
Regular checkup is necessary to look for the progress of the treatment.
Blood tests can be done to check the effect of drug.
If the symptoms do not improve much, consult your doctor again.
Do not start any other drug, prescription or non-prescription, without consulting your physician.
Get emergency help in case of an overdose.
Store it in a dry place at room temperature. Keep it away from the reach of children.
5 Potential side effects
Make sure you meet with your doctor in using Activella to avoid unwanted potential side effects.
There is no drug in the world which is without its unwanted effects. Some drugs are relatively safe for use while for some drug, the patient should be cautious as these drugs may cause more harm than good.
Patient should always get medical help in case of any adverse effect, no matter how much trivial it is.
The most dreadful risk associated with this combination drug is the increase in the risk of endometrial and breast cancer.
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