Amturnide

1 What is Amturnide?

Brand: Amturnide

Generic: Aliskiren, Amlopidine and Hydrochlorothiazide

Aliskiren and amlodipine is a combination of medications that can be used alone or with other medications to treat hypertension (high blood pressure).

Hypertension adds to the workload of the heart and arteries. If it continues fo a long time, the heart and arteries may not function properly.

This can damage the blood vessels of the heart, brain and kidneys, resulting in a stroke, heart failure or kidney failure. Lowering blood pressure will reduce the risk of strokes and heart attacks.

Aliskiren is a renin inhibitor. It works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten.

As a result, the blood vessels relax and this decreases blood pressure. When blood pressure is lowered, the amount of blood and oxygen that go to the heart is increased.

Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow or urine, which helps lower the blood pressure.

Amlodipine is a calcium channel blocker (CCB). It affects the movement of calcium into the cells of the heart and blood vessels.

This results in the relaxation of the blood vessels and increases the supply of blood and oxygen to the heart while reducing the workload of the heart and arteries.

This medication is only available with your doctor’s prescription. This medication is available in the tablet form.

2 What to Know Before Using

As with all medicines, the risks must be compared to how much a medication will help you. This is a decision that you and your doctor will make together.

For this medication, there are many things that need to be considered:

Allergies: Inform your doctor if you have ever had an allergic reaction to doxorubicin or to any other medications. It is also important to inform your doctor of any non-medicine allergies such as foods, dyes, preservatives or animals.

Pediatric: No appropriate studies have been performed on the relationship of age to the effects of this medication in children. Safety and efficacy have not been established.

Geriatric: Up-to-date studies have not shown any problems specific to the elderly that would limit the use of this medication in the elderly population.

Pregnancy: This medication is listed as Pregnancy Category D. This means that studies in pregnant women have demonstrated a risk to the unborn child. However, the benefits of this medication in a life-threatening situation or serious disease may outweigh the potential risk.

Breastfeeding: There are no up-to-date studies in women for determining infant risk when using this medication while breastfeeding. Weigh the potential risks with the benefits before taking this medication while breastfeeding.

Drug Interactions: Certain medications should not be used together. However, in certain cases, two medications may be used together, even if an interaction might occur.

In these cases, your doctor may want to change your dose or take other precautions. When taking this medication, it is important that you inform your doctor if you are taking any of the medications listed below.

The following interactions were selected on the basis of potential significance and are not all-inclusive.

  • Azilsartan
  • Azilsartan Medoxomil
  • Benazepril
  • Candesartan
  • Captopril
  • Dofetilide
  • Enalapril
  • Enalaprilat
  • Eprosartan
  • Fosinopril
  • Irbesartan
  • Lisinopril
  • Losartan
  • Moexipril
  • Olmesartan Medoxomil
  • Perindopril
  • Quinapril
  • Ramipril
  • Telmisartan
  • Trandolapril
  • Valsartan

Using this medication with any of the following is not recommended. Your doctor may decide not to treat you with this medication, or change some of the other medications you take:

  • Acetyldigoxin
  • Amiodarone
  • Amphetamine
  • Arsenic Trioxide
  • Atazanavir
  • Ceritinib
  • Clarithromycin
  • Clopidogrel
  • Conivaptan
  • Cyclophosphamide
  • Cyclosporine
  • Dabrafenib
  • Dantrolene
  • Deslanoside
  • Digitalis
  • Digitoxin
  • Digoxin
  • Domperidone
  • Droperidol
  • Eliglustat
  • Fentanyl
  • Flecainide
  • Idelalisib
  • Itraconazole
  • Ketanserin
  • Lacosamide
  • Levomethadyl
  • Lithium
  • Lomitapide
  • Methotrexate
  • Metildigoxin
  • Nilotinib
  • Ouabain
  • Piperaquine
  • Proscillaridin
  • Simeprevir
  • Simvastatin
  • Sotalol
  • Tacrolimus
  • Tegafur
  • Telaprevir
  • Tocophersolan

Using this medication with any of the following medication is not recommended, but may be unavoidable in some cases.

Your doctor may make the decision not to treat you with this medication or change some of the other medications you take:

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Amtolmetin Guacil
  • Aspirin
  • Benazepril
  • Bepridil
  • Bromfenac
  • Bufexamac
  • Captopril
  • Carbamazepine
  • Celecoxib
  • Cholestyramine
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Delapril
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Enalapril
  • Enalaprilat
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Furosemide
  • Ginkgo
  • Gossypol
  • Ibuprofen
  • Ibuprofen Lysine
  • Imidapril
  • Indinavir
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Proglumetacin
  • Propionic Acid
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Ramipril
  • Rifampin
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Spirapril
  • Sulindac
  • Temocapril
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Trandolapril
  • Valdecoxib
  • Zofenopril

Other Interactions: Certain medications should not be used while eating, or while eating certain foods in the case of negative interactions.

Using alcohol or tobacco with certain medications may also cause negative interactions. Talk with your doctor about the use of your medication with food, alcohol or tobacco.

Using this medication with any of the following is not normally recommended, but may be unavoidable.

If used together, your doctor may change the dose or how often you take your medication or give you special instructions about the use of food, alcohol or tobacco:

  • Grapefruit Juice

Other Medical Problems: Pre-existing medical problems may affect the use of this medication.

Be sure to tell your doctor if you have any other medical problems, especially:

  • Angioedema (swelling of the face, mouth, arms, legs, or throat) - May increases the risk of this condition occurring again.
  • Anuria (not able to pass urine)
  • Diabetes patients who are also taking certain blood pressure medicines such as angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs)
  • Kidney disease
  • Sulfa drug allergy (i.e. sulfamethoxazole, sulfasalazine, Azulfidine®, Bactrim®, Septra®) - Should not be used in patients with these conditions.
  • Asthma - May increase likelihood of having an allergic reaction.
  • Diabetes
  • Kidney problems - May increase risk of having high potassium in the blood.
  • Electrolyte imbalances (i.e. high or low levels of calcium, magnesium, potassium, or sodium in the body)
  • Fluid imbalances (caused by dehydration, vomiting, or diarrhea)
  • Glaucoma, secondary angle closure
  • Gout
  • Hyperlipidemia (high cholesterol or fats in the blood)
  • Liver disease
  • Myopia (changes in the eyeball causing vision problems)
  • Systemic lupus erythematosus (SLE) - Use with caution. May make these conditions worse.
  • Heart or blood vessel disease - Use with caution. May increase the risk of experiencing chest pain or heart attacks.
Have a question aboutHigh Blood Pressure?Ask a doctor now

3 Proper Usage

This medication should not be the first option to treat your condition. It is meant to be used only after you have tried other medication that has not worked or have caused unwanted side effects.

This medication comes with a patient information brochure. It is very important that your read this information. Ask your doctor if you have any questions.

Along with this medication, treatment for your hypertension may include weight control and changes in your diet, especially eliminating foods high in sodium.

Your doctor will tell you which options are most important for you. Ask your doctor before changing your diet.

Many patients with hypertension will not notice any signs of a problem and many patients feel normal.

It is very important that you take your medication and that you keep your appointments with your doctor, even if you are feeling well.

This medication will not cure your hypertension, but it will help control it. You must continue to take your medication if you expect to lower your blood pressure and keep it down.

You may have to take hypertension medication for the rest of your life. If hypertension is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke or kidney disease.

Take this medication at the same time every day.

Dosing: Different patients will be given a different dose of this medication based on the strength of the medication.

The number of doses you take each day, the time between doses and the length of time you take this medication depends on the reason you are taking this medication.

The following information only includes the average dose of this medication. If your dose is different, do not change it without first speaking to your doctor.

  • Adults - Your doctor will determine your starting dose as needed and may increase the dose as needed. The dose is not normally more than 300mg of aliskiren and 10mg of amlodipine and 25mg of hydrochlorothiazide once a day.
  • Children - Use and dose must be determined by your doctor.

Missed dose: If you miss a dose of this medication, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and resume your normal dosing schedule. Do not double dose.

Storage: Store this medication in a closed container at room temperature. Keep it away from heat, moisture, and direct light. Do not freeze. Keep our of the reach of children.

Do not keep expired medication or medication you no longer need. Ask your doctor how to dispose of any medication you do not use.

4 Precautions to Take

It is very important that your doctor checks in with you often while you are receiving this medication to make sure that it is working properly. Blood tests may be needed to check for unwanted effects.

Using this medication while pregnant can harm your unborn child. Use an effective form of birth control to keep from becoming pregnant.

Inform your doctor immediately if you believe you have become pregnant while using this medication.

This medication may cause a condition called angioedema. Inform your doctor immediately if you experience swelling of the face, arms, legs, eyes, lips, tongue or throat, or problems with swallowing and breathing.

Dizziness, lightheadedness or fainting (syncope) may occur after you take this medication, especially when taking a diuretic (water pill). Getting up slowly may lessen this problem.

If you feel dizzy, lie back down so you do not faint. Sit for a few moments before standing to prevent the dizziness or lightheadedness from returning.

Make sure you know how you react to this medication before driving, using machinery or doing anything else that could be dangerous if you are dizzy.

Inform your doctor immediately if you become sick while taking this medication, especially if you have severe or continuous nausea, vomiting or diarrhea.

These conditions may cause you to lose too much water or salt and may lead to hypotension (low blood pressure). You can also lose water by sweating, so it is important to drink plenty of water during exercise or hot weather.

Hyperkalemia (high potassium in the blood) may occur while taking this medication.

Inform your doctor immediately if you have abdominal or stomach pain, confusion, difficulty breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet or lips, shortness of breath or weakness or heaviness in the legs.

Do not use supplements or salt substitutes containing potassium without first asking your doctor.

Inform any doctor or dentist who treats you that you are using this medication. You may need to stop using this medication several days before a surgery or medical condition.

Drinking alcohol or taking narcotic pain relievers or sleeping pills with this medication may intensify feelings of lightheadedness, dizziness or faintness.

Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

This medication may affect blood sugar levels. Inform your doctor if you notice a change in the results of your blood or urine sugar tests or if you have any questions.

Do not take any other medications without asking your doctor, including over the counter medications for appetite control, asthma, colds, cough, allergies or sinus problems, as these may increase your blood pressure.

5 Potential Side Effects

Only take this medication as directed by your doctor. Do not take more, less or for a longer or shorter period of time than your doctor tells you.

This medication comes with a patient information brochure. It is very important that your read this information. Ask your doctor if you have any questions.

More common:

  • Bloating or swelling of the face, arms, hands, lower legs or feet
  • Tingling of the hands or feet
  • Unusual weight gains or loss

Less common:

Rare:

Some side effects that may occur do not normally need medical attention. These may leave as your body becomes accustomed to treatment.

Ask your doctor about ways to prevent or reduce some of these side effects.

Talk to your doctor if any of the following side effects continue or are bothersome, or if you have questions:

Less common:

  • Acid or sour stomach
  • Fever
  • Headache
  • Itching skin
  • Lack or loss of strength
  • Muscle aches
  • Rash
  • Sore throat
  • Stomach discomfort upset or pain
  • Stuffy or a runny nose

Some patients may experience other side effects that are not listed. Check with your doctor if you notice any other side effects.

Ask your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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