Antinaus 50

1 What is Antinaus 50?

Brand: Antinaus 50, Phenergan, Promacot, Prorex

Generic: Promethazine

Antinaus 50, a phenothiazine derivative is used to relieve or prevent some types of allergy or allergic reactions.

It works by preventing the effects of a substance called histamine, which is produced by the body. By blocking the naturally occurring histamine in our body it acts as an antihistamine.

This medicine affords protection of motion sickness but produces sedation and dryness of mouth. It can also be used in morning sickness, radiation sickness, insomnia, drug induced and postoperative vomiting.

This medicine is only available with your doctor's prescription. This product is available in solution form.

2 What to Know Before Using

Before using Antinaus 50, you must know all about the risks and complications associated with it. The suitable drug therapy is chosen by a doctor with the active participation of the patient.

There are some important factors such as drug interactions, the presence of any metabolic impairment, history of hypersensitivity reaction, pregnancy, lactation etc. that may alter the desired therapeutic effects of a medicine.

Sometimes the presence of other health disorders affects the beneficial effects of this medicine and even may cause serious toxic effects.

The use of this medicine is contraindicated in certain medical conditions such as known hypersensitivity reactions, coma, porphyria, cardiac disease, hypokalemia, pregnancy, lactation, neonates and young adults.

Make sure you tell your doctor if you have any other medical problems, especially:

In addition, certain medicines should not be used along with this medicine. It is always recommended to consult with your doctor if you are in need of some other medications or even any over-the-counter medicine for another health problem in order to avoid unwanted toxic effects.

In addition, you should have the knowledge of following drug interactions before you start receiving this medicine:

  • Masks ototoxicity of aminoglycoside antibiotics
  • May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates, and opioids.
  • Potentially fatal condition i.e. ventricular arrhythmias may develop when used with drugs that prolong QT interval.

Studies over animal have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of this medicine in pregnant women despite potential risks.

3 Proper Usage

To use Antinaus 50 properly, you must follow all instructions given by your doctor. The dosage schedule and the duration of drug therapy depend on the particular medical problem for which you are going to use this medicine.

The therapeutic dose may also vary with the patient’s condition or requirement and the strength of the medicine as well.

For allergic conditions:

An adult can be treated with 25-50 mg (as hydrochloride), given via IM or slow IV injection or injected into the tubing of a freely running infusion at a concentration of not >25 mg/ml and infused at a rate of not >25 mg/min. Maximum dose: 100 mg.

The dose and duration of treatment in case of a child should be determined by a pediatrician. Further, dose reduction may be required in patients with renal impairment.

This medicine is usually given to the patients by a nurse or other trained health professional at your doctor’s chamber, hospital, or clinic. Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way.

Further, it is advised to store the medicine in a closed container at room temperature away from heat, moisture, and direct light. All kinds of medicines should be kept out of the reach of children. However, outdated medicines should be disposed of by an appropriate way.

4 Precautions to Take

Before using Antinaus 50, there are some precautions you must take. Firstly, regular visits to your doctor are recommended to check the prognosis while undergoing any drug therapy. Additionally, the following guidelines should be followed:

  • Make sure you tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • Do not use any prescription or nonprescription medicine, herbal preparation, or dietary supplement without checking with your doctor.
  • Use this drug cautiously in elderly patients because they are more sensitive to its side effects.
  • It is not recommended to use this medicine in children because the safety and effectiveness have not been confirmed.
  • Some laboratory tests (e.g. blood cell counts, kidney function tests, liver function tests, etc.) may be carried out to monitor your condition or check for side effects.
  • Promethazine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Check with your doctor immediately if you or your child think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
  • This medicine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute.
  • This drug should not be used in those with asthma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction, epilepsy, glaucoma, and impaired liver function.
  • Driving a car, using machinery or any other activity that requires alertness should not be performed as promethazine makes you dizzy or drowsy or cause blurred vision.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Antinaus 50. These side effects usually go away during the treatment episode as your body adjusts to the medicine.

Your healthcare professional may advise you about the ways how to prevent or reduce those unwanted side effects.

Sometimes you may need to consult with the doctor immediately if you notice any of the following toxic effects, especially:

Other side effects not listed may also occur in some patients while receiving this drug therapy. If you face any other problem regarding using this medicine you should immediately consult with a doctor.