1 What is Aphthasol?

Brand: Aphthasol

Generic: Amlexanox

Aphthasol is widely prescribed to treat aphthous ulcers (canker sores). This medicine accelerates healing of aphthous ulcers but the exact mechanism of action is not known.

In vitro studies have shown that Aphthasol is a potent inhibitor of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils, and mononuclear cells.

This medicine is available in the market as a paste. You can get this product only with your doctor's prescription.

2 What to Know Before Using

Before using Aphthasol, you must know all about the risks and complications associated with it. The suitable drug therapy is usually chosen by a doctor with the active participation of the patient.

There are some important factors such as drug interactions, the presence of any metabolic impairment, history of hypersensitivity reaction, pregnancy, lactation etc. which may alter the desired therapeutic effects of a medicine.

Sometimes the presence of other health disorders affects the beneficial effects of this medicine and even may cause serious complications. If you have had any allergic reactions to any medicine then you must inform your doctor about that.

The use of amlexanox is contraindicated in those who are hypersensitive to any of the ingredients of this product. Further, make sure your doctor if you have any other medical problems, especially immunity related disorders.

Because of drug-drug interactions, certain medicines should not be used along with another medicine. It is always recommended to consult with your doctor if you are in need of some other medications or even any over-the-counter medicine for another health problem in order to avoid unwanted toxic effects.

Animal reproduction studies have not shown any adverse effect on the fetus and there are no adequate and well-controlled studies in humans. But animal reproduction studies are not always predictive of human response.

Thus, this drug should be used during pregnancy only if clearly needed. Besides, caution should be exercised when used in lactating women because there are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

3 Proper Usage

To use Aphthasol properly, you must follow all instructions given by your doctor. The dosage schedule and the duration of drug therapy generally depend on upon the particular medical problem for which you are going to use this medicine. The therapeutic dose may also vary with the patient’s condition or requirement and the strength of the medicine as well.

For treatment of aphthous ulcers (canker sores):

  • Adults— should apply approximately 0.5 cm of oral paste directly onto each ulcer in the mouth four times a day following oral hygiene after meals and before you go to bed.
  • Children—dosages should be determined by a pediatrician and not to be used in children below 12 years of age.

To use the mucosal-local dosage form (oral paste) of this medicine, you should follow these guidelines:

  • You should initiate the use of amlexanox at earliest symptom of an aphthous ulcer.
  • Oral hygiene should be maintained before you apply the paste.
  • You should wash your hands with soap and water before and after using this product.
  • Squeeze a small amount of the paste (about 1/4 inch) onto your fingertip.
  • Then, dab the paste onto each ulcer in your mouth using gentle pressure.

If you miss a dose of this medicine, take it as soon as possible. But, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use this drug in larger amounts, more often, or for a longer time than your doctor ordered.

Further, it is advised to store the medicine in a closed container at room temperature away from heat, moisture, and direct light. All kinds of medicines should be kept out of the reach of children. However, outdated medicines should be disposed of by an appropriate way.

4 Precautions to Take

Before using Aphthasol, there are some precautions you must take. Firstly, regular visits to your doctor are recommended to check that this medicine is working properly or not.

Additionally, the following guidelines should be followed to prevent unwanted complications as well as for the better prognosis of the patients:

  • This product is intended for mucosal-local use on the ulcer only. Be aware of not getting any of the paste in your eyes. If any gets in your eyes, wash them out with water right away.
  • You should continue treatment until mouth ulcer is healed but not exceeding 10 days.
  • If the ulcers have not healed within 10 days, check with your doctor.
  • If you notice any application site reaction, check with your physician.
  • The lower initial dose is recommended in elderly patients.
  • Effects have not been evaluated in immune-compromised patients.
  • This medicine should not be used in children under age 12.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Aphthasol. 

Transient pain, stinging, burning sensation, irritation, and contact dermatitis have been reported as application site reactions following the application of this medicine. Nausea and vomiting may also occur in some patients.

These side effects usually go away during the treatment episode as your body adjusts to the medicine. In addition, your healthcare professional may advise you about the ways how to prevent or reduce those unwanted side effects.

Sometimes other side effects not listed may also occur in some cases. Further, if you notice any excessive toxicity, then you should stop using the paste and check with your doctor immediately.