Aspirin, Sodium Bicarbonate, And Citric Acid

1 What is Aspirin, Sodium Bicarbonate, And Citric Acid?

Generic: Aspirin, sodium bicarbonate, and citric acid (Oral Route)

Aspirin, sodium bicarbonate, and citric acid combination is used as pain reliever for patients experiencing heartburn, sour stomach, or acid indigestion. It may also be used to lower the chance of stroke, heart attack or other problems that may occur when a blood vessel is blocked by blood clots.

Aspirin is a salicylate and an anti-inflammatory analgesic that is used to relieve pain. This also prevents blood cloths from forming. However, this may also increase the chance of serious bleeding in some people.

Sodium bicarbonate is an antacid that neutralizes stomach acid by combining with it to form a new substance that is not an acid.

2 What to Know Before Using

Tell to your doctor if you are allergic to Aspirin, Sodium Bicarbonate, and Citric Acid or to any other medications.

This medicine may cause Reye’s syndrome in children if taken with fever, especially if the fever is caused by a virus infection. Discuss with your child’s doctor first the use and effect of this medicine before giving it to your children.

Elder people are sensitive to the effects of the aspirin and sodium bicarbonate. Discuss with your doctor first the use and effect of this medicine before taking this medication.

Pregnancy category C – Tell your doctor first if you are currently expecting a baby or if you are planning to become pregnant before taking this medication.

There are no adequate studies whether Citric Acid, Potassium Citrate, and Aspirin can pass through breast milk or if it could cause harmful effects to the infant. However, Sodium Bicarbonate can cause minimal risk to the infant during breastfeeding. Discuss with your doctor if you are breastfeeding a baby.

Taking this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dichlorphenamide
  • Live Influenza Virus Vaccine
  • Ketorolac

Taking any of the following medicines with of the following medicines usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or frequency of one or both of your medicines.

  • Abciximab
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amphetamine
  • Anagrelide
  • Anisindione
  • Apixaban
  • Ardeparin
  • Argatroban
  • Beta Glucan
  • Bivalirudin
  • Certoparin
  • Cilostazol
  • Citalopram
  • Clomipramine
  • Clopidogrel
  • Cyclosporine
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desipramine
  • Desirudin
  • Desvenlafaxine
  • Dibenzepin
  • Dicumarol
  • Dipyridamole
  • Dipyrone
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Elvitegravir
  • Enoxaparin
  • Eptifibatide
  • Erlotinib
  • Escitalopram
  • Feverfew
  • Flufenamic Acid
  • Fluoxetine
  • Fluvoxamine
  • Fondaparinux
  • Gefitinib
  • Ginkgo
  • Gossypol
  • Heparin
  • Imipramine
  • Ketoconazole
  • Ketoprofen
  • Ledipasvir
  • Lepirudin
  • Levomilnacipran
  • Lofepramine
  • Mefenamic Acid
  • Melitracen
  • Memantine
  • Methotrexate
  • Milnacipran
  • Nadroparin
  • Naproxen
  • Nefazodone
  • Nortriptyline
  • Opipramol
  • Parnaparin
  • Paroxetine
  • Pazopanib
  • Pemetrexed
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Phenindione
  • Phenprocoumon
  • Piroxicam
  • Pralatrexate
  • Prasugrel
  • Propyphenazone
  • Protein C
  • Protriptyline
  • Reteplase, Recombinant
  • Reviparin
  • Rivaroxaban
  • Sertraline
  • Sulindac
  • Tacrolimus
  • Tianeptine
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Treprostinil
  • Trimipramine
  • Varicella Virus Vaccine
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin

Taking this medicine with any of the following medications may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or frequency of one or both of your medicines.

  • Acebutolol
  • Alprenolol
  • Amiloride
  • Arotinolol
  • Atenolol
  • Azosemide
  • Befunolol
  • Bemetizide
  • Bendroflumethiazide
  • Benzthiazide
  • Betamethasone
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bopindolol
  • Bucindolol
  • Bumetanide
  • Bupranolol
  • Buthiazide
  • Canrenoate
  • Captopril
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Celiprolol
  • Chlorothiazide
  • Chlorthalidone
  • Clopamide
  • Cortisone
  • Cyclopenthiazide
  • Dasatinib
  • Delapril
  • Dexamethasone
  • Dilevalol
  • Enalaprilat
  • Enalapril Maleate
  • Esmolol
  • Ethacrynic Acid
  • Furosemide
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Imidapril
  • Indapamide
  • Labetalol
  • Landiolol
  • Levobunolol
  • Lisinopril
  • Mepindolol
  • Methyclothiazide
  • Methylprednisolone
  • Metipranolol
  • Metolazone
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Nipradilol
  • Nitroglycerin
  • Oxprenolol
  • Paramethasone
  • Penbutolol
  • Phenylbutazone
  • Pindolol
  • Piretanide
  • Polythiazide
  • Prednisolone
  • Prednisone
  • Probenecid
  • Propranolol
  • Rofecoxib
  • Sotalol
  • Spironolactone
  • Streptokinase
  • Talinolol
  • Tamarind
  • Temocapril
  • Tenecteplase
  • Tertatolol
  • Timolol
  • Torsemide
  • Triamcinolone
  • Triamterene
  • Trichlormethiazide
  • Valproic Acid
  • Xipamide

Some medical conditions can interact with this medication. Tell your doctor if you have any of the following conditions:

3 Proper Usage

Tell your doctor if you are on a low sodium or low sugar diet since this medicine contains a large amount of sodium. Do not take this medicine if it has a strong vinegar-like odor. This odor means the aspirin in it is breaking down.

To use this medicine:

  • Put the prescribed tablet into a glass then add 4 ounces of cool water.
  • Make sure to dissolve the tablets in the water. Do not swallow the tablets or any pieces of the tablets.
  • Add a little more water to the glass and drink that to make sure that you get the remaining medicine in the glass.


The dosage varies for different patients. Take this medicine exactly as prescribed by your doctor.

Oral dosage forms (effervescent tablets) for pain and upset stomach:

  • Adults and teenagers—One or two regular-strength (325-milligram) tablets every four to six hours as needed, one extra-strength (500-mg) tablet every four to six hours as needed, or two extra-strength (500-mg) tablets every six hours as needed, dissolved in water. Elderly people should not take more than four regular-strength or extra-strength tablets a day. Other adults and teenagers should not take more than 6 regular-strength flavored tablets, 8 regular-strength unflavored tablets, or 7 extra-strength tablets a day.
  • Children—Use and dose must be determined by your doctor.
    • Children younger than 3 years of age: Use and dose must be determined by your doctor.
    • Children 3 to 5 years of age: One-half of a regular-strength (325-mg) tablet, dissolved in water, every four to six hours as needed.
    • Children 6 to 12 years of age: One regular-strength (325-mg) tablet, dissolved in water, every four to six hours as needed.

Required dosage for reducing the chance of heart attack, stroke, or other problems that may occur when a blood vessel is blocked by blood clots:

  • Adults—One regular-strength (325-mg) tablet a day, dissolved in water.
  • Children and teenagers—Use and dose must be determined by your doctor.

If you miss a dose of this medicine, take it as soon as possible. However, if it is near for your next dose, skip the missed dose and start again to your regular dosing schedule. Do not take a double dose to make up for a missed one.

Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of reach of children. Do not keep expired medications.

4 Precautions To Take

Check with your doctor on regular visits to monitor your progress with the medication especially if you will be taking this medicine for a long time (more than 5 days in a row for children or 10 days in a row for adults).

Check with your doctor if your pain and/or upset stomach last for more than 10 days for adults or 5 days for children or if they get worse, if new symptoms occur, or if the painful area is red or swollen.

Taking this medicine with laxative that contains cellulose near together may decrease the effects of aspirin. You should take this combination medicine at least 2 hours before or after you take the laxative.

Tell your doctor if you are taking any other medication that contains salicylate or sodium contents. Taking other salicylate-containing or other sodium-containing products together with this medicine may cause an overdose.

Do not take aspirin for 5 days before any surgery unless otherwise directed by your physician to prevent bleeding problems.

Do not use beyond your prescribed dose. Call your doctor for instructions. Also, do not stop taking this medicine for any reason without first checking with the doctor who directed you to take it.

For diabetic patients, monitor your blood sugar regularly since this medication may affect your blood sugar. Check with your doctor right away if you any change in the results of your urine blood sugar tests. Aspirin can cause inaccurate urine glucose test results if you regularly take 8 or more 324-mg, or 4 or more 500-mg (extra-strength), tablets a day.

Call for help immediately if think you or someone else may have taken an overdose of this medicine. Signs of an overdose include convulsions, hearing loss, confusion, ringing or buzzing in the ears, severe drowsiness or tiredness, severe excitement or nervousness, and fast or deep breathing.

If you are taking any of the following medications, always take this medicine:

  • At least 8 hours before or 2 hours after taking enoxacin.
  • At least 6 hours before or 2 hours after taking ciprofloxacin or lomefloxacin.
  • At least 3 or 4 hours before or after taking a tetracycline antibiotic by mouth.
  • At least 3 hours before or after taking ketoconazole.
  • At least 2 hours before or after taking norfloxacin or ofloxacin.
  • At least 2 hours after taking itraconazole.
  • At least 1 or 2 hours before or after taking any other medicine by mouth.

If you will be taking more than 1 or 2 doses of this medicine:

  • Do not drink alcoholic beverages as this may increase the chance of stomach problems.
  • Do not drink a lot of milk or eat a lot of milk products to prevent chances of having side effects.
  • Limit the amount of sodium in the foods you eat.
  • Tell the doctor in charge that you are taking this medicine before undergoing to any medical tests. The results of some tests may be affected by this medicine.

The following medication contains salicylate and may increase the chance of undesirable effects. Follow your doctor’s directions carefully if he/she directs you to take these medicines together on a regular basis:

  • Acetaminophen
  • Diclofenac
  • Diflunisal
  • Etodolac
  • Fenoprofen
  • Floctafenine
  • Flurbiprofen, oral
  • Ibuprofen
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Meclofenamate
  • Mefenamic acid
  • Nabumetone
  • Naproxen
  • Oxaprozin
  • Phenylbutazone
  • Piroxicam
  • Sulindac
  • Tenoxicam
  • Tiaprofenic acid
  • Tolmetin

5 Potential Side Effects

If any of the following side effects occur, check with your doctor right away.

Signs and symptoms of overdose in children:

  • Changes in behavior
  • Severe drowsiness or tiredness
  • Fast or deep breathing
  • Any loss of hearing
  • Bloody urine
  • Confusion
  • Convulsions
  • Severe or persistent diarrhea
  • Difficulty in swallowing
  • Severe dizziness, lightheadedness, or feeling faint
  • Severe drowsiness
  • Severe excitement or nervousness
  • Fast or deep breathing
  • Flushing, redness, or other change in skin color
  • Hallucinations
  • Severe or persistent nausea or vomiting
  • Shortness of breath, troubled breathing, tightness in chest, or wheezing
  • Severe or persistent stomach pain
  • Swelling of eyelids, face, or lips
  • Unexplained fever
  • Uncontrollable flapping movements of the hands (especially in elderly patients)
  • Vision problems

If any of the following side effects occur, check with your doctor immediately.

  • Bloody or black, tarry stools
  • Frequent urge to urinate
  • Severe or persistent headache
  • Increased blood pressure
  • Continuing loss of appetite
  • Mood or mental changes
  • Muscle pain or twitching
  • Continuing ringing or buzzing in ears
  • Skin rash, hives, or itching
  • Slow breathing
  • Swelling of face, fingers, ankles, feet, or lower legs
  • Unpleasant taste
  • Unusual tiredness or weakness
  • Vomiting of blood or material that looks like coffee grounds
  • Unusual weight gain

Less serious side effects: