Autoplex T is widely used for controlling of bleeding episodes or bleeding during surgery in patients who have hemophilia A and hemophilia B. There are some clotting factors normally present in our body that helps to stop bleeding by clot formation.
Anti-inhibitor coagulant complex contains certain coagulation factors (e.g. Factors II, IX, and X, and activated Factor VII) and thereby helps to stop bleeding from injuries in patients with hemophilia by helping the blood to clot.
This product is available in powder form and only available on doctor’s prescription. This powder is used to make a solution and it is administered to the patients only by or under the supervision of a healthcare professional.
2 What to Know Before Using
Before using Autoplex T, you must know all about the risks and complications associated with it. The suitable drug therapy is chosen by a doctor with the active participation of the patient.
There are some important factors such as drug interactions, the presence of any metabolic impairment, history of hypersensitivity reaction, pregnancy, lactation etc. that may alter the desired therapeutic effects of a medicine.
Sometimes the presence of other health disorders may affect the beneficial effects of this medicine and even may cause serious toxic effects.
Thus, you should tell your doctor if you have any other medical problems, especially:
In addition, certain medicines should not be used along with this medicine. Using an anti-inhibitor coagulant complex with drugs like aminocaproic acid and tranexamic acid is not recommended.
It is always advised to consult with your doctor if you are in need of some other medications or even any over-the-counter medicine for another health problem in order to avoid unwanted toxic effects.
Studies over animal have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of this medicine in pregnant women despite potential risks.
3 Proper Usage
To use Autoplex T properly, you must follow all instructions given by your doctor. The dosage schedule and the duration of drug therapy may vary depending upon the particular medical problem for which you are going to use this medicine.
The therapeutic dose has been described below considering the patient’s condition and the strength of the medicine:
Prevention and control of joint hemorrhage: 50 units/kg IV q12hr; may increase to 100 units/kg q12hr; continue until signs of clinical improvement occur but not exceeding 200 mg/kg/day.
Prevention and control of mucous membrane bleeding: 50 units/kg IV q 6hr, may increase to 100 units/kg q 6hr for 2 doses maximum but not exceeding 200 units/kg/day.
Prevention and control of soft tissue hemorrhage: 100 units/kg IV q12hr but not exceeding 200 units/kg/day.
Prevention and control of severe hemorrhage (e.g. CNS bleeding): 100 units/kg IV q 6-12hr but not exceeding 200 units/kg/day unless the severity of hemorrhage justifies higher doses.
Preoperative management: 50-100 units/kg IV once immediately prior to surgery.
Postoperative management: 50-100 units/kg IV q 6-12hr until resolution of bleeding and healing is achieved.
Routine prophylaxis: 85 units/kg IV every other day.
This medicine is usually given to the patients by a nurse or other trained health professional at your doctor’s chamber, hospital, or clinic. This injection is intended for intravenous use. If you want to use this product at home, a healthcare provider will teach you how to use.
Further, it is advised to store the medicine in a closed container at room temperature away from heat, moisture, and direct light. All kinds of medicines should be kept out of the reach of children. However, outdated medicines should be disposed of by an appropriate way.
4 Precautions to Take
Before using Autoplex T, there are some precautions you must take. Firstly, regular visits to your doctor are recommended to check the prognosis while undergoing any drug therapy. Additionally, the following guidelines should be followed:
Platelet count should be done at the time of initial use of the product and if anticipated treatment responses are not achieved. A sufficient number of functionally intact platelets are required for the efficacy of the product.
Besides, estimation of fibrinogen level in blood can be done to see the prognosis.
You should not use this medicine if you are a breastfeeding mother without informing the doctor.
This medicine may increase the chance of unwanted clot formation, especially in patients with atherosclerosis, septicemia, heart attack, or stroke. Thus, you should tell your doctor if you have coronary artery disease or history of heart attack, stroke, or blood clot.
Serious types of allergic reactions may occur, including anaphylaxis. Anaphylaxis requires immediate medical attention and can be life-threatening.
Self-medication should be avoided of this medicine without proper knowledge and training.
Pregnant women should consult with her doctor before taking it as there is a risk of adverse effects on the fetus.
Since this medicine is made from donated human blood, there is a risk of transmission of certain viruses to people who have received them. The risk of getting a virus from medicines made from human blood has been greatly reduced in recent years. Although the risk is low, talk with your doctor if you have concerns.
5 Potential Side Effects
Make sure you meet with your doctor in using Autoplex T to avoid unwanted potential side effects. Along with its needed effects, a medicine may cause some unwanted effects (e.g. pain or redness at the injection site).
These side effects usually go away during the treatment episode as your body adjusts to the medicine. Your healthcare professional may advise you about the ways how to prevent or reduce those unwanted side effects.
Sometimes you may need to consult with the doctor immediately if you notice any of the following toxic effects, especially:
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