Avandamet

1 What is Avandamet?

Brand: Avandamet

Generic: Rosiglitazone And Metformin

Rosiglitazone and Metformin combination is used to treat type 2 diabetes mellitus (noninsulin-dependent diabetes). It is used together with diet and exercise.

Rosiglitazone reduces your blood sugar by improving the muscle, fat and liver's sensitivity to insulin. Metformin reduces the amount of sugar that the liver produces, decreases intestinal absorption of sugar, and improves the body to utilize glucose better. This product is available in tablet.

2 What to Know Before Using

Before taking this medication, tell your healthcare professional first if you are allergic to Rosiglitazone and Metformin combination or to any other medications. Safety and effectiveness of this medication in children have not been established. Although this medicine have not demonstrated geriatric-specific problems, older patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving Rosiglitazone and Metformin combination.

Pregnancy category C – The use of Rosiglitazone and Metformin combination during pregnancy is warranted only if benefits justify risks to the fetus and only when no alternative management is appropriate. Taking this medicine with any of the following medicines is not recommended and you may not be required to use this medication. Otherwise, alternative medicine may be prescribed for your other medications.

  • Acetrizoic acid
  • Diatrizoate
  • Ethiodized oil
  • Iobenzamic acid
  • Iobitridol
  • Iocarmic acid
  • Iocetamic acid
  • Iodamide
  • Iodipamide
  • Iodixanol
  • Iodohippuric acid
  • Iodopyracet
  • Iodoxamic acid
  • Ioglicic acid
  • Ioglycamic acid
  • Iohexol
  • Iomeprol
  • Iopamidol
  • Iopanoic acid
  • Iopentol
  • Iophendylate
  • Iopromide
  • Iopronic acid
  • Ioseric acid
  • Iosimide
  • Iotasul
  • Iothalamate
  • Iotrolan
  • Iotroxic acid
  • Ioversol
  • Ioxaglate
  • Ioxitalamic acid
  • Ipodate
  • Metrizamide
  • Metrizoic acid
  • Tyropanoate sodium

Taking this medicine with any of the following medications is usually not recommended, but with exception in some cases. Dosage or frequency of one or both of your medicines may be changed if both medicines are prescribed together.

  • Abiraterone
  • Acetazolamide
  • Balofloxacin
  • Besifloxacin
  • Bupropion
  • Ceritinib
  • Ciprofloxacin
  • Dabrafenib
  • Dichlorphenamide
  • Dofetilide
  • Dolutegravir
  • Enoxacin
  • Entacapone
  • Fleroxacin
  • Flumequine
  • Gatifloxacin
  • Gemifloxacin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Lanreotide
  • Levofloxacin
  • Lomefloxacin
  • Moxifloxacin
  • Nadifloxacin
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Pasireotide
  • Pazufloxacin
  • Pefloxacin
  • Pixantrone
  • Prulifloxacin
  • Rufloxacin
  • Sparfloxacin
  • Tosufloxacin
  • Vandetanib
  • Zonisamide

Taking this medicine with any of the following medications may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Dosage or frequency of one or both of your medicines may be changed if both medicines are prescribed together.

  • Acebutolol
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Bitter Melon
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Esmolol
  • Fenofibrate
  • Fenofibric Acid
  • Fenugreek
  • Furazolidone
  • Gemfibrozil
  • Glucomannan
  • Guar Gum
  • Iproniazid
  • Isocarboxazid
  • Labetalol
  • Levobunolol
  • Linezolid
  • Methylene Blue
  • Metipranolol
  • Metoprolol
  • Moclobemide
  • Nadolol
  • Nebivolol
  • Nialamide
  • Oxprenolol
  • Penbutolol
  • Phenelzine
  • Pindolol
  • Practolol
  • Procarbazine
  • Propranolol
  • Psyllium
  • Ranolazine
  • Rasagiline
  • Rifampin
  • Safinamide
  • Selegiline
  • Sotalol
  • Timolol
  • Tranylcypromine
  • Trimethoprim

Some medical conditions can interact with this medication. Tell your doctor if you have any of the following conditions:

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3 Proper Usage

Take this medicine exactly as prescribed by your doctor. Excessive use of medication is not recommended. This medicine should be taken with food. You should do regular exercises. Special diet from your doctor should be followed as well. For adult patients with inadequately controlled on diet and exercise, starting dose is 2 mg of Rosiglitazone plus 500 mg of Metformin once or twice a day.

Your doctor may adjust your dose to 8 mg of Rosiglitazone plus 2000 mg of Metformin per day, divided into two doses. For adult patients on Metformin therapy, recommended dosage is 4 mg/day of Rosiglitazone plus the dose of Metformin already being taken, divided into two doses. Your doctor may adjust your dose as necessary. For adult patients on Rosiglitazone therapy, recommended dosage is 1000 mg of Metformin per day plus the dose of Rosiglitazone already being taken, divided into two doses. Your doctor may adjust your dose as necessary.

For patients not on Metformin or Rosiglitazone therapy, recommended dosage is 2 mg of Rosiglitazone plus 500 mg of Metformin once a day or two times a day. Your doctor may adjust your dose up to 8 mg of Rosiglitazone plus 2000 mg of Metformin per day, divided into two doses. For adult patients previously treated with Rosiglitazone and Metformin, the dose is the same as the dose you are already taking. Your doctor may adjust your dose as necessary.

If you miss a dose of this medicine, take it as soon as possible. However, if it is near for your next dose, skip the missed dose and start again to your regular dosing schedule. Do not take a double dose to make up for a missed one. Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of reach of children. Do not keep expired medications.

4 Precautions to Take

Check with your doctor if:

  • If you have chest pain or discomfort, nausea, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, sweating, or vomiting. These may be symptoms of a heart attack.
  • If you are rapidly gaining weight or having shortness of breath, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor right away. These may be symptoms of a heart problem or edema.
  • If you have abdominal or stomach pain, dark urine, a loss of appetite, nausea or vomiting, unusual tiredness or weakness, or yellow eyes or skin. These may be symptoms of a serious liver problem.
  • If blurring of vision, difficulty in reading, or any other change in vision occurs while you are taking this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist.

Your doctor will be checking you regularly to monitor the effectiveness of the medication. Blood tests may be ordered for undesirable effects. Tell your doctor that you are using this medicine before undergoing any kind of surgery or medical procedures. Excessive intake of Metformin can cause lactic acidosis especially in people with serious health problems.

The symptoms of lactic acidosis include abdominal or stomach discomfort, decreased appetite, diarrhea, fast or shallow breathing, a general feeling of discomfort, muscle pain or cramping, and unusual sleepiness, tiredness, or weakness. Call for medical help if you have more than one of these symptoms together.

Some pregnant women who are taking this medicine can be at risk. This medicine may cause ovulation for women who are having ovulation problems or those who had irregular periods in the past. This may increase their chance of becoming pregnant. Discuss birth control options with your doctor if you are a woman of childbearing potential.

Rosiglitazone and Metformin combination may increase the risk for bone fractures in women. Discuss with your doctor the ways to keep your bones strong to help prevent fractures. Drinking alcohol while using this medication may cause severe low blood sugar. Discuss with your doctor if you have any concerns with this matter. Avoid using any other medication without discussing it first with your doctor.

Discuss with your doctor the ways on how to prevent side effects of this medication. In addition, diabetic patients may need special counseling regarding pregnancy as well as diabetes medicine dosing changes that might occur due to lifestyle changes. When are planning to travel, you should keep your recent prescription as well as your medical history with you. You should make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.

Carrying a medical identification card stating that you have diabetes can be helpful in emergency cases. Fluid retention may lead to heart problems if worsened. You should know what to do if fluid retention occurs. Rosiglitazone and metformin combination can cause low blood sugar. Symptoms of low blood sugar include:

  • Anxiety
  • Behavior change similar to being drunk
  • Blurred vision
  • Cold sweats
  • Confusion
  • Cool
  • Pale skin
  • Difficulty in thinking
  • Drowsiness
  • Excessive hunger
  • Fast heartbeat
  • Persistent headache
  • Nausea
  • Nervousness
  • Nightmares
  • Restless sleep
  • Shakiness
  • Slurred speech
  • Unusual tiredness or weakness

Management for low blood sugar include eating glucose tablets or gel, corn syrup, honey, or sugar cubes, or drink fruit juice, non-diet soft drinks, or sugar dissolved in water. You should also monitor your blood sugar levels. In addition, you should always have a Glucagon kit with you if severe symptoms of low blood sugar occur. Members of your family also should know how to use it.

If you are not taking this medication correctly, high blood sugar can occur. Symptoms of high blood sugar include:

  • Blurred vision
  • Drowsiness
  • Dry mouth
  • Flushed
  • Dry skin
  • Fruit-like breath odor
  • Increased urination (frequency and amount)
  • Ketones in the urine
  • Loss of appetite
  • Sleepiness
  • Stomachache
  • Nausea or Vomiting
  • Tiredness
  • Troubled breathing (rapid and deep)
  • Unconsciousness
  • Unusual thirst

Check your blood sugar level and consult with your doctor for instructions.

5 Potential Side Effects

If any of the following side effects occur, check with your doctor right away:

  • Pale skin
  • Troubled breathing with exertion
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Anxiety
  • Blurred vision
  • Chest pain or discomfort
  • Chills
  • Cold sweats
  • Coma
  • Confusion
  • Cool, pale skin
  • Depression
  • Dilated neck veins
  • Dizziness
  • Extreme fatigue
  • Fast heartbeat
  • Headache
  • Increased hunger
  • Irregular breathing
  • Irregular heartbeat
  • Nausea
  • Nightmares
  • Seizures
  • Shakiness
  • Slurred speech
  • Swelling of the face, fingers, feet, or lower legs
  • Weight gain
  • Abdominal or stomach discomfort
  • Decreased appetite
  • Diarrhea
  • Fast, shallow breathing
  • General feeling of discomfort
  • Muscle pain or cramping
  • Sleepiness
  • Change in vision
  • Dark urine
  • Decreased urine output
  • Hives or welts, itching, or skin rash
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • Pain or discomfort in the arms, jaw, back, or neck
  • Redness of the skin
  • Stomach pain
  • Sweating
  • Vomiting

Less serious side effects:

  • Body aches or pain
  • Cough, fever, sneezing, or sore throat
  • Difficulty with breathing
  • Ear congestion
  • Loss of voice
  • Pain or tenderness around the eyes and cheekbones
  • Stuffy or runny nose
  • Back pain
  • Cold or flu-like symptoms
  • Difficulty with moving
  • Pain in the joints

Not all side effects are listed above. If you notice any other effects, check with your healthcare professional.

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