1 What is Aventyl?

Brand: Aventyl, Pamelor

Generic: Nortriptyline

Nortriptyline is a tricyclic antidepressant that is used for treatment of depression. It works by affecting the activity of serotonin in the brain.

This product is available in:

  • Tablet
  • Capsule
  • Solution

2 What to Know Before Using

Tell to your doctor if you are allergic to Nortriptyline or to any other medications. You should also inform your healthcare providers if you are allergic to foods, dyes, or animals.

Safety and effectiveness of this medication have not been established in children.

There are no specific problems that would limit the usefulness of Nortriptyline in the elderly. However, elderly patients are prone to have undesirable side effects which may require medical attention.

This medication poses minimal risk to the infant when used during breastfeeding.

Taking Nortriptyline with any of the following medicines is not recommended and you may not be required to use this medication. Otherwise, alternative medicine may be prescribed for your other medications.

  • Dronedarone
  • Furazolidone
  • Grepafloxacin
  • Iproniazid
  • Isocarboxazid
  • Levomethadyl
  • Linezolid
  • Methylene Blue
  • Metoclopramide
  • Moclobemide
  • Pargyline
  • Phenelzine
  • Procarbazine
  • Ranolazine
  • Rasagiline
  • Safinamide
  • Selegiline
  • Tranylcypromine

Taking Nortriptyline with any of the following medications is usually not recommended, but with exception in some cases. Dosage or frequency of one or both of your medicines may be changed if both medicines are prescribed together.

  • Acecainide
  • Aceclofenac
  • Acemetacin
  • Albuterol
  • Alfuzosin
  • Almotriptan
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • AmtolmetinGuacil
  • Apomorphine
  • Aprindine
  • Arsenic Trioxide
  • Asenapine
  • Aspirin
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bretylium
  • Bromfenac
  • Bufexamac
  • Bupropion
  • Celecoxib
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Choline Salicylate
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clonidine
  • Clonixin
  • Crizotinib
  • Cyclobenzaprine
  • Darunavir
  • Dasatinib
  • Desipramine
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Dextromethorphan
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Droperidol
  • Droxicam
  • Enflurane
  • Epinephrine
  • Erythromycin
  • Etilefrine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fingolimod
  • Flecainide
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Foscarnet
  • Frovatriptan
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroxytryptophan
  • Ibuprofen
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indomethacin
  • Iobenguane I 123
  • Isoflurane
  • Isradipine
  • Ketoprofen
  • Ketorolac
  • Lapatinib
  • Levalbuterol
  • Levomilnacipran
  • Levothyroxine
  • Lidoflazine
  • Lopinavir
  • Lorcainide
  • Lorcaserin
  • Lornoxicam
  • Loxoprofen
  • Lumefantrine
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Meperidine
  • Methadone
  • Methoxamine
  • Midodrine
  • Mifepristone
  • Mirtazapine
  • Moricizine
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Naratriptan
  • Nefopam
  • Nepafenac
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Norepinephrine
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Oxaprozin
  • Oxilofrine
  • Oxymorphone
  • Oxyphenbutazone
  • Paliperidone
  • Palonosetron
  • Parecoxib
  • Paroxetine
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Phenylbutazone
  • Phenylephrine
  • Piketoprofen
  • Piroxicam
  • Posaconazole
  • Pranoprofen
  • Procainamide
  • Prochlorperazine
  • Proglumetacin
  • Promethazine
  • Propafenone
  • Propyphenazone
  • Proquazone
  • Protriptyline
  • Quinidine
  • Quinine
  • Risperidone
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sematilide
  • Sertindole
  • Sertraline
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Sodium Salicylate
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sulindac
  • Sultopride
  • Sumatriptan
  • Sunitinib
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tenoxicam
  • Tetrabenazine
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Toremifene
  • Tramadol
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Valdecoxib
  • Vardenafil
  • Vasopressin
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Ziprasidone
  • Zolmitriptan
  • Zotepine

Taking Nortriptyline with any of the following medications may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Dosage or frequency of one or both of your medicines may be changed if both medicines are prescribed together.

  • Acenocoumarol
  • Arbutamine
  • Atomoxetine
  • Carbamazepine
  • Cimetidine
  • Dicumarol
  • Phenprocoumon
  • Rifapentine
  • S-Adenosylmethionine
  • Terbinafine
  • Valproic Acid

Some medical conditions can interact with this medication. Tell your doctor if you have any of the following conditions:

3 Proper Usage

Take Nortriptyline exactly as prescribed by your doctor. Excessive use of medication is not recommended.

Oral liquid medicine should be measured with a marked measuring spoon, oral syringe, or medicine cup.

Recommended dosage of Nortriptyline (capsules or solution) for adults is 25 milligrams 3 to 4 times per day. Your doctor may adjust your dose up to 150 mg/day. For teenagers and older adults, recommended dosage is 30 to 50 milligrams once a day or in divided doses during the day.

If you miss a dose of this medicine, take it as soon as possible. However, if it is near for your next dose, skip the missed dose and start again to your regular dosing schedule. Do not take a double dose to make up for a missed one.

Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of reach of children. Do not keep expired medications.

4 Precautions to Take

Your doctor will be checking you regularly to monitor the effectiveness of the medication. Blood tests may be ordered for undesirable effects.

Patients who are taking this medication should be aware that this medication can increase thoughts of suicide. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Check with your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Also, tell your doctor if you have a family history of bipolar disorder or if anyone in your family has tried to commit suicide.

Do not take Nortriptyline with a monoamine oxidase (MAO) inhibitor. Do not start taking nortriptyline during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping nortriptyline before you start taking a MAO inhibitor. You may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions if you take them together or do not wait 2 weeks.

Do not use Nortriptyline with buspirone, fentanyl, lithium, tryptophan, St. John's wort, or some pain or migraine medicines. Talk to your doctor if you are planning to take any other medication.

Do not use beyond your prescribed dose. Call your doctor for instructions. Also, do not stop taking this medicine for any reason without first checking with the doctor who directed you to take it.

Nortriptyline will add to the effects of alcohol and other CNS depressants. Check with your doctor before taking CNS depressants while you are using this medicine.

Tell your doctor that you are using this medicine before undergoing any kind of surgery or emergency treatment. This medicine may cause drowsiness. Avoid driving, operating machineries, or any other unsafe activities when you take this medication.

5 Potential Side Effects

If any of the following side effects occur, check with your doctor right away:

  • Abdominal or Stomach pain
  • Agitation
  • Blurred vision
  • Burning, Crawling, Itching, Numbness, Prickling, "Pins and Needles", or Tingling feelings
  • Chest pain or discomfort
  • Clay-colored stools
  • Cold sweats
  • Confusion about identity, place, and time false beliefs that cannot be changed by facts
  • Continuing ringing or buzzing or other unexplained noise in the ears
  • Decreased urination
  • Depression
  • Difficulty in passing urine (dribbling)
  • Difficulty with speaking
  • Dizziness, Faintness, or Lightheadedness when getting up suddenly from a lying or sitting position
  • Double vision
  • Fast, Pounding, or Irregular heartbeat or pulse
  • Feeling of warmth
  • Feeling, Seeing, or Hearing things that are not there
  • Feeling that others are watching you or controlling your behavior
  • Feeling that others can hear your thoughts
  • General feeling of tiredness or weakness
  • Hostility
  • Hyperventilation
  • Inability to move the arms, legs, or facial muscles
  • Inability to speak
  • Irritability
  • Loss of balance control
  • Lower back or side pain
  • Mood or mental changes
  • Muscle spasm or jerking of all extremities
  • Muscle trembling, jerking, or stiffness
  • Nightmares
  • Pain or Discomfort in the arms, jaw, back, or neck
  • Painful or Difficult urination
  • Panic
  • Perspiration
  • Pinpoint red or purple spots on the skin
  • Redness of the face, neck, arms, and occasionally, upper chest
  • Restlessness
  • Seizures
  • Slurred speech
  • Sores, Ulcers, or White spots on the lips or in the mouth
  • Stiffness of the limb
  • Sweating
  • Swelling of the face, ankles, legs, or hands
  • Talking, Feeling, and Acting with excitement
  • Trouble sleeping
  • Twisting movements of the body uncontrolled movements, especially of the face, neck, and back
  • Weakness in the arms, hands, legs, or feet

There are also some side effects that do not need medical attention and can be resolved during treatment as your body adjusts to the medicine. You can discuss it to your doctor to give you an advice on how to prevent or reduce these side effects:

  • Bigger, Dilated, or Enlarged pupils (black part of the eye)
  • Black tongue
  • Decreased interest in sexual ability or desire
  • Difficulty having a bowel movement (stool)
  • Enlargement of the breast
  • Hair loss or thinning of the hair
  • Heartburn
  • Hives or Welts
  • Increase in sexual ability or desire
  • Increased sensitivity of the eyes or skin to light
  • Pain or Discomfort in the chest, upper stomach, or throat
  • Peculiar taste
  • Severe sunburn
  • Small red or purple spots on the skin
  • Swelling of the testicles
  • Swelling or Inflammation of the mouth
  • Swollen, Painful, or Tender lymph glands on side of face or neck
  • Vision changes
  • Waking to urinate at night

Not all side effects are listed above. If you notice any other effects, check with your healthcare professionals.

6 Related Clinical Trials