Medicines should be used following the directions were given by a doctor. The dose of this medicine will vary according to patient’s condition or requirements.
You should follow the doctor's directions and advice. The amount of medicine that you take must not exceed the maximum therapeutic dose.
Also, the frequency of your daily drug administration and the duration of drug therapy depend on the particular medical problem for which you are taking the medicine.
Certain ocular beta-blockers are widely used in both chronic simple (wide angle) glaucoma and angle closure (narrow-angle) glaucoma. They are:
Timolol: it is the prototype of ocular beta-blockers which is non-selective and has no local anesthetic or intrinsic sympathomimetic activity.
The ocular hypotensive action becomes evident within 1 hour and lasts for ~12 hours. After chronic dosing, the action is smooth and well sustained.
You should start with 0.25% drops twice in a day in case of open-angle glaucoma which can be changed to 0.5% drops in case of inadequate response.
Additionally, topical beta-blocker such as timolol 0.5% is instilled 12 hourly as an adjuvant in angle closure glaucoma.
Betaxolol: it is beta-1 selective blocker offering the advantage of less bronchopulmonary and probably less cardiac, central and metabolic side effects.
In addition, it appears to exert a protective effect on retinal neurons. 0.5% eye drops are usually used in open-angle glaucoma. One drop should be instilled in each eye twice daily.
Levobunolol: it has been introduced as a once-daily alternative to timolol. The ocular and systemic effects are very similar to timolol except for the longer duration of action.
Other ocular beta-blockers: Carteolol and metipranolol.
Always try to take your medicine in time. If you miss any dose of this medicine, you should take it as soon as possible.
But when it is time for your next dose, then skip the missed dose and go back to your regular dosing schedule.
You should store the medicine in a closed container at room temperature away from heat, moisture, and direct light.
All kinds of medicines should be kept out of the reach of children. Outdated medicine must be disposed of by an appropriate way.
4 Precautions to Take
Some important measures should be taken if you feel any discomfort following any drug therapy.
In the case of such drug therapy, you may not need to discontinue the therapy as there are least chances of drug toxicity.
But you should not delay consulting with your physician in case of extreme unwanted effects.
Systemic adverse effects can be minimized by applying mild pressure on the inner canthus of the eye for about 5 min. after instilling the eye drop to prevent entry of the drug into the naso-lacrimal duct from where it is mainly absorbed.
5 Potential Side Effects
Actually, there are some unwanted side-effects associated with each drug that usually do not need medical attention.
These side-effects usually go away during the treatment episode as your body adjusts to the medicine.
Additionally, your health care professional may advise you about the ways how to prevent or reduce those unwanted side-effects.
Sometimes you may need to consult with the doctor if you feel any serious discomfort.
The following side effects may warrant medical care immediately:
Ocular side effects are generally mild and infrequent and they are stinging, redness and dryness of the eye, corneal hypoesthesia, allergic blepharoconjunctivitis and blurred vision.
Systemic adverse effects are the major limitations in the use of ocular beta-blockers and occur due to absorption through nasolacrimal duct.
Life-threatening bronchospasm has been reported in asthmatic and COPD patients. Bradycardia, accentuation of heart block and CHF are likely, especially in the elderly.
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