1 What is Blephamide?

Brand: Blephamide

Generic: Prednisolone Acetate + Sulfacetamide Sodium

Blephamide is a steroid/anti-infective combination for steroid-responsive inflammatory eye conditions with bacterial infection or with a risk for such. This product contains prednisolone, a steroid and sulfacetamide sodium, an antibiotic effective against infections caused by organisms such as Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus (viridans group), Haemophilusinfluenzae, Klebsiella species, and Enterobacter species.

Blephamide is available as an eye suspension containing prednisolone acetate 2 milligram in 1 milliliter, sulfacetamide sodium 100 milligram in 1 milliliter. It is also available as an ointment.


  • For eye drops:

Wash your hands prior to application. Do not touch the dropper tip or let it touch your eye or any other object to avoid contamination. Next, tilt your head and look upward. Pull down the lower lid and place one drop into the eye. Place one finger at one corner of the eye and press gently to prevent the solution from draining out. Do not rub the treated eye. Repeat as directed. Do not rinse the dropper and replace cap after use.

This medication should not be used while wearing contact lenses. Consult your doctor or pharmacist for details.

Other eye drugs should be used at least 5 minutes after applying this drug. Use eye drops before eye ointments.

  • For eye ointment, see the package insert for more information.

If your condition persists or worsens, consult your doctor.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Blephamide may interact with medications such as:

  • Gentamicin
  • Certain local anesthetics (e.g., tetracaine)
  • Preparations that contain silver

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to sulfacetamide/prednisolone or to sulfa drugs (e.g., sulfamethoxazole) and corticosteroids (e.g., hydrocortisone, prednisone)
  • Eye problems (e.g., glaucoma, severely dry eyes)
  • Eye surgeries (e.g., cataract surgery)
  • Diabetes
  • Pregnancy or lactation
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