1 What is Butisol?

Brand: Butisol

Generic: Butabarbital Sodium

Butisol is a drug which is a sedative or hypnotic. This drug is used in treating insomnia.

Butisol is available as an oral solution containing butabarbital sodium 30 milligram in 5 milliliter. It is also available as a tablet containing either 30 mg or 50 mg of butabarbital sodium.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Butisol may interact with medications such as:

  • Darunavir
  • Felbamate
  • Lopinavir
  • MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
  • Disulfiram
  • Phenytoin
  • Valproic acid
  • St. John's wort
  • Cyclosporine
  • Doxycycline
  • Estrogens
  • Griseofulvin
  • Metronidazole
  • Ranolazine
  • Blood thinners such as warfarin
  • Corticosteroids such as prednisone
  • Calcium channel blockers such as felodipine/nimodipine
  • Alcohol
  • Antihistamines (such as cetirizine, diphenhydramine)
  • Tricyclic antidepressants (such as amitriptyline)
  • Drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem)
  • Muscle relaxants
  • Narcotic pain relievers (such as codeine)

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to butabarbital or to other barbiturates (such as phenobarbital)
  • Certain hormone problems (adrenal disease such as Addison's disease)
  • Liver problems
  • Kidney problems
  • Lung disease (such as sleep apnea, chronic obstructive pulmonary disease-COPD)
  • Mental/mood disorders (such as depression, thoughts of suicide)
  • History of alcohol/substance abuse
  • Personal/family history of a certain blood disorder (porphyria)
  • Pregnancy or lactation