Clinoril

1 What is Clinoril?

Brand: Clinoril

Generic: Sulindac

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of mild to moderate pain and help relieve symptoms of arthritis or acute gout in different joints of the body, such as inflammation, swelling, stiffness, and joint pain

This medicine does not cure arthritis and will help you only as long as you continue to take it. This drug requires a prescription.

2 What to Know Before Using

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. 

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies regarding the relationship of age to the effects of sulindac in the pediatric population have not been performed while safety and efficacy have not been established. Studies in the elderly have not reported geriatric-specific problems that would limit the usefulness of sulindac. 

Adjustments in the dose of elderly patients may be required since they are more sensitive to the effects of sulindac than younger adults, and are more likely to have age-related kidney problems. Adverse effects have been reported but there are no adequate studies in pregnant women or animals. 

Studies are still inadequate in determining infant risk when taking this during breastfeeding. Discuss with your healthcare professional the potential risks and benefits before taking this drug while breastfeeding. Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects. 

Inform your healthcare professional if you are taking any other drugs such as Ketorolac, Abciximab, Amineptine, Amitriptyline, Amitriptylinoxide, Amoxapine, Anagrelide, Apixaban, Ardeparin, Argatroban, Aspirin Beta Glucan, Bivalirudin, Certoparin, Cilostazol, Citalopram, Clomipramine,Clopidogrel, Cyclosporine, Dabigatran, Etexilate, Dalteparin, Danaparoid, Desipramine, Desirudin, Desvenlafaxine, Dibenzepin, Dipyridamole, Dothiepin, Doxepin, Duloxetine, Edoxaban, Enoxaparin, Eptifibatide, Erlotinib, Escitalopram, Feverfew, Fluoxetine, Fluvoxamine, Fondaparinux, Ginkgo, Gossypol, Heparin, Imipramine, Lepirudin, Levomilnacipran, Lofepramine, Meadowsweet, Melitracen, Methotrexate, Milnacipran, Nadroparin, Nefazodone, Nortriptyline, Opipramol, Parnaparin, Paroxetine, Pemetrexed, Pentosan, Polysulfate Sodium, Pentoxifylline, Pralatrexate, Prasugrel, Protein C, Protriptyline, Reboxetine, Reviparin, Rivaroxaban, Sertraline, Sibutramine, Tacrolimus, Tianeptine, Ticlopidine, Tinzaparin, Tirofiban, Trimipramine, Venlafaxine, Vilazodone, Vortioxetine, Acebutolol, Acenocoumarol, Alacepril, Alprenolol, Amiloride, Arotinolol, Atenolol, Azosemide, Befunolol, Bemetizide, Benazepril, Bendroflumethiazide, Benzthiazide, Betaxolol, Bevantolol, Bisoprolol, Bopindolol, Bucindolol, Bumetanide, Bupranolol, Buthiazide, Canrenoate, Captopril, Carteolol, Carvedilol, Celiprolol, Chlorothiazide, Chlorthalidone, Cilazapril, Clopamide, Cyclopenthiazide, Delapril, Dicumarol, Dilevalol, Enalapril, Enalaprilat, Esmolol, Ethacrynic Acid, Fosinopril, Furosemide, Hydrochlorothiazide, Hydroflumethiazide, Imidapril, Indapamide, Labetalol, Landiolol, Levobunolol, Lisinopril, Lithium, Mepindolol, Methyclothiazide, Metipranolol, Metolazone, Metoprolol, Moexipril, Nadolol, Nebivolol, Nipradilol, Oxprenolol, Penbutolol, Pentopril, Perindopril, Pindolol, Piretanide, Polythiazide, Propranolol, Quinapril, Ramipril, Sotalol, Spirapril, Spironolactone, Talinolol, Temocapril, Tertatolol, Timolol, Torsemide, Trandolapril, Triamterene, Trichlormethiazide, Warfarin, Xipamide, or Zofenopril. 

Intake of specific food or using alcohol or tobacco with magnesium is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. 

Inform your healthcare provider for any other medical problems such as anemia, bleeding problems, blood clots, edema, heart attack, heart disease, hypertension, kidney or liver disease, pancreatitis, stomach ulcers or intestinal bleeding, history of stroke, aspirin-sensitive asthma or aspirin sensitivity, history of heart surgery, or systemic lupus erythematosus.

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3 Proper Usage

This drug must be taken exactly as directed by your doctor. To prevent any side effects, take this drug exactly as directed in the label or as prescribed by your healthcare professional. Follow the specific directions on the label or as prescribed by your healthcare professional. 

This drug must be taken regularly patients with severe or continuing arthritis. It usually takes one week before the drug begins to work, but in severe cases up to two weeks or even longer may pass before you begin to feel better. 

Take this drug with food and increase your fluid intake for faster excretion of this drug in the urine and help prevent kidney problems. The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed. 

The dosage of this drug you take depends on the medical problem for which you are using this drug. Adults with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis are given 150 milligrams tablets two times a day. The dose must not exceed 400 mg per day. 

Adults with acute gout, bursitis, or tendinitis are given 200 milligrams tablets two times a day. Use and dose in children must determined by your healthcare professional. A lower dose may be given for a while when your condition improves before treatment is completely stopped. 

A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. 

Keep from freezing. Keep out of the reach of children. Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

Your healthcare provider should closely monitor the effectiveness of this drug as well as check for unwanted effects.  Unwanted effects can be detected using blood and urine tests. A risk of having a heart attack or stroke in persons with underlying heart disease or with prolonged use has been associated with this drug. 

This is more likely in people who already have heart disease. Bleeding in your stomach or intestines has also been associated with prolonged use in patients with stomach ulcer in the past, smokers or regular alcohol drinkers, over 60 years of age, in poor health, or using other medicines such as a steroid medicine or a blood thinner. 

Consult with your doctor right away if you have any of the following symptoms of serious skin reactions such as blistering, peeling, loosening of the skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, white spots in the mouth or on the lips, or unusual tiredness or weakness. 

Warning signs of serious side effects that can occur during treatment with this drug may include black, tarry stools, decreased urination, severe stomach pain, skin rash, swelling of the face, fingers, feet, or lower legs, unusual bleeding or bruising, unusual weight gain, vomiting of blood or material that looks like coffee grounds, or yellow skin or eyes. 

Also, signs of serious heart problems could occur such as chest pain, fast or irregular heartbeat, tightness in the chest, unusual flushing or warmth of skin, weakness, or slurring of speech. Consult with your healthcare professional immediately if you notice any of these warning signs. This medicine may cause a serious type of allergic reaction called anaphylaxis. 

Contact emergency medical services immediately if  symptoms of anaphylaxis such as very fast or irregular breathing, gasping for breath, wheezing, or fainting, color change of the face, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, and puffiness or swelling of the eyelids or around the eyes. 

This drug has teratogenic potential in infants. Inform your healthcare professional if you think you have become pregnant while using the drug. Consult with your healthcare professional if you experience symptoms of problems with your pancreas such as bloating, chills, constipation, darkened urine, fast heartbeat, fever, indigestion, loss of appetite, nausea, pains in the stomach, side, or abdomen, possibly radiating to the back, vomiting, or yellow eyes or skin. 

Your healthcare professional will refer you to an ophthalmologist if you experience blurred vision, difficulty in reading, or any other change in vision that occurs during or after your treatment. 

Contact emergency medical services immediately if you experience symptoms of meningitis such as confusion, drowsiness, a fever, a general feeling of illness, a headache, loss of appetite, nausea, a stiff neck or back, or vomiting. 

Inform your healthcare professional that you are taking this drug before having any medical test. Consult with you healthcare professional before taking other prescription or non-prescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

Side effects may vary for each individual and prompt medical attention should be given if they occur. 

Inform you healthcare provider immediately if you experience symptoms such as acid or sour stomach, belching, constipation, headache, heartburn, nausea or vomiting, skin rash, stomach pain, excess air or gas in the stomach or intestines, itching skin, passing gas, stomach cramps, swelling, weight loss, back or leg pains, bleeding gums, blistering, peeling, or loosening of the skin, bloating, bloody or black, tarry stools, bloody or cloudy urine, blurred or loss of vision, burning feeling in the chest or stomach, burning while urinating, chest pain, chills, clay-colored stools, confusion, cough or hoarseness, cracks in the skin, dark urine, decreased urine output, diarrhea, difficult or labored breathing, difficult or painful urination, difficulty with swallowing, dilated neck veins, discoloration of urine, disturbed color perception, dizziness, double vision, extreme fatigue, eye pain, fainting, feeling of warmth, fever flu-like symptoms, general body swelling, general feeling of discomfort or illness, groin pain, halos around lights, hives, increased sensitivity of the skin to sunlight, increased sweating, increased thirst, indigestion, irregular breathing, joint or muscle pain, large, flat, blue, or purplish patches in the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, light-colored stools, loss of appetite, loss of heat from the body, lower back or side pain, muscle aches, pains, or weakness nervousness, night blindness, noisy breathing, nosebleeds, numbness or tingling in the hands, feet, or lips, overbright appearance of lights, painful or difficult urination, pains in the stomach, side, or abdomen, possibly radiating to the back, pale skin, persistent bleeding or oozing from puncture sites, mouth, or nose pinpoint red or purple spots on the skin, pounding in the ears, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center red, irritated eyes, redness of the face, neck, arms and occasionally, upper chest redness or other discoloration of the skin redness, swelling, or soreness of the tongue, scaly skin, seizures, severe or continuing stomach pain, severe sunburn, shortness of breath slow or fast, irregular, pounding, or racing heartbeat or pulse, sore throat, sores, ulcers, or white spots in the mouth or on the lips, stiff neck or back, stomach upset, swelling of the face, fingers, feet, or lower legs, swelling or inflammation of the mouth, swollen or painful glands, tenderness in the stomach area, tightness in the chest, troubled breathing, tunnel vision, unpleasant breath odor, unusual bleeding or bruising, unusual tiredness or weakness, upper right abdominal pain, vomiting of blood or material that looks like coffee grounds, watery or bloody diarrhea, weakness or heaviness of the legs, weight gain, wheezing yellow eyes or skin.  

Contact emergency medical services if symptoms of overdose occur such as change in consciousness, decreased awareness or responsiveness, loss of consciousness, severe sleepiness. Some side effects may occur that usually do not need medical attention. 

These side effects may go away during treatment as your body adjusts to the medicine. Ask your healthcare professional about ways to prevent or reduce some of these side effects. If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. 

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

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