Clolar

1 What is Clolar?

Brand: Clolar

Generic: Clofarabine injection

Clofarabine injection is a purine nucleoside anti-metabolite used for the treatment of cancer of the white blood cells called acute lymphoblastic leukemia (ALL). 

Clofarabine is an antineoplastic that kills cancer cells by inhibiting their DNA synthesis and repair. Unwanted effects can occur as this drug can also exert its effects on normal cells of the body. 

Consult with your healthcare professional about the risks and benefits of this drug before starting any treatment regimen. 

This drug is to be given only by or under the immediate supervision of your healthcare professional.

2 What to Know Before Using

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. 

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in children 1 year of age and older have not demonstrated any pediatric-specific problems that would limit the usefulness of clofarabine injection. 

The relationship of age to the effects of clofarabine injection has not been determined in the studies of geriatric population. Safety and efficacy have not been established in elderly patients 65 years of age.  Studies in pregnant women have demonstrated a risk to the fetus but the benefits of therapy may outweigh this risk in a life threatening situation or a serious disease. 

Development of any infant risk is still undetermined when taking this drug during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. 

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects. 

Inform your healthcare professional if you are taking any other drugs such as Dasabuvir. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. 

Intake of specific food or using alcohol or tobacco with magnesium is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. 

Inform your healthcare provider for any other medical problems such as anemia, any form of infection, liver or kidney disease, neutropenia, or thrombocytopenia.

Have a question aboutAcute Lymphoblastic Leukemia?Ask a doctor now

3 Proper Usage

You will receive this drug only in a hospital or cancer treatment center. A doctor or other trained health professional will give you this drug. 

This drug is given intravenously through a needle placed in one of your veins. Increase in fluid intake is recommended to facilitate better excretion of this drug and prevent any kidney problems.

4 Precautions to Take

Your healthcare provider should closely monitor the effectiveness of this drug as well as check for unwanted effects. Unwanted effects can be checked using blood and urine tests. This drug is teratogenic and it can harm your unborn baby when you are taking this drug during pregnancy. 

Use of effective forms of birth control is recommended to prevent pregnancy. Inform your healthcare professional immediately if you experience symptoms of pregnancy.  Your body’s resistance may be lowered when taking clofarabine. 

Consult with your healthcare professional before taking any vaccination during or after treatment with this drug to prevent any infection from vaccines. Also, avoid people who have recently taken oral polio vaccine or those who have been immunized to prevent polio infection. 

Wear a protective face mask to cover your nose and mouth if you cannot make these precautions. Unwanted effects such as infection and bleeding can occur by taking this drug. An increased chance of getting an infection can be caused by this drug by temporarily lowering the number of white blood cells in your blood. 

Platelet number can also be lowered, which are needed proper blood clotting. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. 

When you suspect an infection, if you are experiencing fever or chills, cough or hoarseness, lower back or side pain, painful or difficult urination, or if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin, consult with your healthcare professional immediately. 

Toothbrush, dental floss, or toothpick should be used with care.  Other ways to clean your teeth and gums can be recommended by your healthcare professional. Before having any dental work done, consult with your healthcare professional. 

Observe proper hand washing before touching your eyes or the inside of your nose. Be careful when handling sharp tools or objects to prevent any unwanted open wounds which can be an entry of infection. Activities which can cause bruising or injury should be avoided. 

Inform your healthcare professional if you experience any symptoms of tumor lysis syndrome such as hyperuricemia. Consult with your healthcare professional immediately if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, a fast or irregular heartbeat, shortness of breath, or swelling of the hands, ankles, feet, or lower legs. 

These may be symptoms of rare but serious conditions called capillary leak syndrome or systemic inflammatory response syndrome (SIRS).  Seek advice from your healthcare professional immediately if you have symptoms of a serious liver problem such as stomach pain, pale stools, or dark urine, a loss of appetite, or yellow eyes or skin. 

These could be. Consult with your healthcare professional before taking any other prescription or non-prescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

 Side effects may vary for each individual and prompt medical attention should be given if they occur. Inform you healthcare provider immediately if you experience any unusual symptoms such as: abdominal or stomach pain or tenderness

  • rash, black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • bloody nose
  • blurred vision
  • burning or stinging of the skin
  • chest pain
  • chills clay-colored stools
  • cold or flu-like symptoms
  • confusion
  • cough or hoarseness
  • dark urine 
  • decreased urine output
  • diarrhea
  • difficult or labored breathing
  • dilated neck veins
  • dizziness
  • faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • facial swelling
  • fainting
  • fast, pounding, or irregular heartbeat or pulse feeling of warmth
  • fever
  • flushing
  • redness of the skin
  • headache
  • irregular breathing
  • itching
  • itching in the genital area
  • joint pain
  • stiffness
  • or swelling
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • nausea
  • nervousness
  • pain
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid, shallow breathing
  • redness of the face, neck, arms, and occasionally, upper chest redness
  • swelling, or skin pain scaling of the skin on the hands and feet
  • severe abdominal or stomach cramps with pain
  • skin rash
  • slow or fast heartbeat
  • small red or purple spots on the skin
  • sneezing
  • sore throat sores
  • ulcers
  • white spots on the lips or in the mouth
  • sweating
  • swelling of the ankles, feet, or lower legs
  • swelling or inflammation of the mouth
  • swollen glands
  • tenderness
  • tightness in the chest
  • tingling of the hands and feet
  • troubled breathing with exertion, 
  • ulcers
  • sores or white spots in the mouth
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusually warm skin
  • vomiting
  • vomiting of blood
  • warmth on the skin
  • watery and severe diarrhea, which may also be bloody
  • weight gain
  • yellow eyes or skin
  • agitation
  • bloating
  • blue lips and fingernails
  • chest pain or discomfort
  • cloudy urine
  • constipation
  • coughing that sometimes produces a pink frothy sputum
  • darkened urine
  • decrease or increase in the amount of urine
  • decreased level of consciousness
  • depression
  • difficult, fast, or noisy breathing
  • sometimes with wheezing
  • dry mouth
  • general feeling of discomfort or illness
  • hives
  • hostility
  • hyperventilation
  • increased sweating
  • indigestion
  • irritability
  • muscle aches and pains
  • muscle twitching
  • pain or tenderness around the eyes and cheekbones
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • rapid weight gain
  • restlessness
  • seizures
  • shaking
  • shivering
  • stuffy or runny nose
  • swelling of the eyelids, face, lips, or hands
  • trouble sleeping
  • blistering
  • peeling or loosening of the skin red irritated eyes red skin lesions, often with a purple center

Some side effects may occur that usually do not need medical attention. These side effects will eventually disappear as your body adjusts to the drug. Ask your healthcare professional about ways to prevent or reduce some of these side effects. 

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. 

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

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