Coly-Mycin M

1 What is Coly-Mycin M?

Brand: Coly-Mycin M, Coly-Mycin M Parenteral

Generic: Colistimethate

Colistimethate injection is a polymixin antibiotic for the treatment of different infections of the body.

This drug kills bacteria by disrupting their cell membrane through a detergent-like mechanism. This drug is ineffective against viral infections. This drug requires a prescription.

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2 What to Know Before Using

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children have not demonstrated any pediatric-specific problems that would limit the utility of colistimethate injection.

Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of colistimethate injection in the elderly.

Adjustments in the dose of the elderly may be since they are more likely to have age-related kidney problems.

Adverse effects have been reported in animals but studies in pregnant women or animals are still inadequate. Development of any infant risk is still undetermined when taking this drug during breastfeeding.

Discuss with your healthcare provider about the benefits and risks of this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as Amikacin, Capreomycin, Gentamicin, Kanamycin, Neomycin, Paromomycin, Streptomycin, Tobramycin, Alcuronium, Atracurium, Cisatracurium, Doxacurium, Fazadinium, Gallamine, Hexafluorenium, Metocurine, Mivacurium, Pancuronium, Pipecuronium, Rapacuronium, Rocuronium, Tubocurarine, and Vecuronium.

Intake of specific food or using alcohol or tobacco with colistimethate is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems especially diarrhea, lung or kidney disease

3 Proper Usage

A trained healthcare professional will be the only one to give you this drug.

This drug may be administered intravenously through a needle placed in one of your veins, or intramuscularly as a shot into your muscle.

Also, this drug can be inhaled in gaseous form through a nebulizer to treat lung infections. Mix the drug before putting it in the nebulizer for a breathing treatment.

Dispose of any leftover liquid of the drug that is not used. Ask your health care professional for instructions on how to properly mix and take this drug.

4 Precautions to Take

Consult with your healthcare professional If your symptoms do not improve or if they become worse within a few days.

This drug may cause dizziness or numbness and tingling sensations in the hands, toes, and feet.

Be careful in taking this drug before you drive, use machines, or do anything else that could be dangerous. Seek advice from your health care professional if these symptoms are especially inconvenient.

Serious breathing problems have been associated with this drug when administered intramuscularly. Seek prompt medical attention if this happens.

This drug may cause diarrhea and consult with your healthcare professional first before you take any anti-diarrheal drug as this may worsen the diarrhea worse or prolong it.

Contact emergency medical services immediate if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain.

5 Potential Side Effects

Side effects may vary for each individual and prompt medical attention should be given if they occur.

Inform you healthcare provider immediately if you experience any unusual symptoms such as:

  • blood in the urine
  • bluish lips or skin
  • burning
  • crawling
  • itching
  • numbness
  • prickling
  • "pins and needles", or tingling feelings
  • change in frequency of urination or amount of urine
  • the decrease in the amount of urine
  • the difficulty with breathing
  • drowsiness
  • fever
  • increased thirst
  • loss of appetite
  • nausea or vomiting
  • shortness of breath
  • slurred speech
  • swelling of the feet or lower legs
  • tightness in the chest
  • tingling of the arms, legs, and tongue
  • trouble breathing
  • weakness
  • wheezing, or symptoms of overdose such as dizziness
  • mood or mental changes
  • shakiness and unsteady walk
  • uncontrolled eye movements
  • unsteadiness
  • trembling, or other problems with muscle control or coordination
  • unusual drowsiness
  • dullness
  • tiredness
  • weakness
  • the feeling of sluggishness

Some side effects may occur that usually do not need medical attention. As your body adjusts to the drug, these side effects may eventually disappear.

Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

Report any side effects to the FDA hotline at 1-800-FDA-1088.