1 What is Compro?

Brand: Compro

Generic: Prochlorperazine

Brand name:


Compro is a drug which controls severe nausea and vomiting in adults. This drug is available as a rectal suppository which contains 25 mg of Prochlorperazine.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be used rectally as instructed by your doctor. Remain lying down for a few minutes after insertion. Avoid having bowel movement for an hour or longer.

Your dosage is based on your medical condition and the way you will respond to treatment.

This does not apply


Compro may interact with medications such as:

  • Dofetilide
  • Certain drugs that increase dopamine activity (e.g., cabergoline, pergolide)
  • Certain drugs that may affect the heart rhythm (e.g., cisapride, halofantrine, sparfloxacin, pimozide)
  • Epinephrine for low blood pressure
  • Metrizamide
  • Sibutramine
  • Alpha blockers (e.g., prazosin)
  • Anticholinergics (e.g., atropine, scopolamine)
  • Anti-seizure drugs (e.g., carbamazepine)
  • Guanethidine/guanadrel
  • Narcotic pain relievers (e.g., codeine)
  • Bupropion
  • Isoniazid (INH)
  • Other phenothiazines (e.g., thioridazine)
  • Theophylline
  • Tramadol
  • Tricyclic antidepressants (e.g., amitriptyline)

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to prochlorperazine or to other phenothiazines (e.g., chlorpromazine)
  • Blood disorders (e.g., bone marrow depression)
  • Ongoing breathing problems (e.g., asthma, emphysema)
  • Certain heart rhythm problems (e.g., prolonged QTc interval, irregular heartbeat)
  • Low blood pressure
  • Glaucoma
  • Liver problems (e.g., cirrhosis)
  • Reye's syndrome
  • Seizures
  • Urination problems (e.g., trouble urinating due to enlarged prostate, urinary retention)
  • Pregnancy or lactation