1 What is Cortenema?

Brand: Cortenema

Generic: Hydrocortisone Rectal Enema

Brand name:


Hydrocortisone rectal enema is a drug used in the treatment of ulcerative colitis. This drug is available as a rectal enema containing hydrocortisone 100 milligrams.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This drug is to be used in the rectum as directed usually once nightly before bedtime for about 2 to 3 weeks or until symptoms go away.

Your dosage is based on your medical condition and the way you will respond to treatment. Use this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Hydrocortisone rectal enema may interact with medications such as:

  • Aldesleukin
  • Blood thinners such as:
    • Warfarin
  • Natalizumab
  • Quinolone antibiotics such as:
    • Ciprofloxacin
    • or Levofloxacin
  • Vaccines
  • Drugs that may cause low potassium blood level such as:
    • Amphotericin B
    • Hydrochlorothiazide
    • or Furosemide

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to hydrocortisone or to other corticosteroids such as:
    • Prednisone
  • Gastrointestinal problems
  • Infections such as:
  • Certain eye conditions such as:
  • Heart problems
  • High blood pressure
  • Liver disease
  • Kidney disease
  • Thyroid problems
  • Diabetes
  • Osteoporosis
  • Bleeding or blood clotting problems
  • Mental or mood conditions
  • Low potassium or calcium blood levels
  • Myasthenia gravis
  • Pregnancy or lactation
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