1 What is Corzide?

Brand: Corzide

Generic: Nadolol and bendroflumethiazide

Brand name: 


The combination of Nadolol and Bendroflumethiazide, administered through the oral route, is prescribed in patients with hypertension or high blood pressure. If you have hypertension, you are at risk of developing worsening cardiovascular problems including heart attacks. This is mainly because increased blood pressure can add to the workload of your heart and blood vessels, which can lead to dysfunction and damage in the long run. Controlling blood pressure is, therefore, necessary to maintain a steady equilibrium.

Nadolol and Bendroflumethiazide are two different kinds of drugs. The former belongs to a drug class called beta-blockers. Its mechanism of action involves decreasing the body’s response to certain nerve impulses. This is helpful in controlling blood pressure since it causes the heart to beat slower. Blood flow and oxygen distribution are then improved.

Bendroflumethiazide, on the other hand, is commonly called a water pill or a diuretic. It lowers the blood pressure by decreasing water in the body through increased urination. This particular combination can only be purchased with a prescription from your primary care physician. It is usually in tablet form.

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2 What to Know Before Using

There are several factors you need to consider before using this medication for treatment. Discuss the pros and cons with your physician. Your healthcare team must be made aware of any drug, food, preservative, and animal allergies. If you have sensitivity reactions to drugs of the same kind, inform your doctor.

There is not enough research on the effects of Nadolol and Bendroflumethiazide combination treatment in children, so safety and efficacy are not known. On the flip side, studies on the geriatric population have found that the efficacy of this medication is not affected by age-related conditions. It is important to note though that elderly patients may have liver, kidney and heart illnesses that could increase or decrease the effects of the nadolol and bendroflumethiazide combination. This particular combination is a pregnancy category C, which means that there isn’t enough research on its effects in pregnant mothers and their unborn child. The same holds true in breastfeeding mothers. You need to discuss risks and benefits of using the nadolol and bendroflumethiazide combination while nursing with your physician. Other medications can interact with this drug. Tell your healthcare team about other medicines you are taking.

The dosage of the following drugs can be adjusted if simultaneous treatment with Nadolol and Bendroflumethiazide combination is necessary although it is not usually recommended. These include:

  • Acetyldigoxin
  • Amiodarone
  • Bepridil
  • Clonidine
  • Deslanoside
  • Digitalis
  • Diltiazem
  • Dronedarone
  • Fingolimod
  • Lacosamide
  • Lithium
  • Sotalol
  • Verapamil

Using these medicines is also not recommended since these medications can increase certain side effects. This include:

  • Acarbose
  • Aspirin
  • Bunazosin
  • Celecoxib
  • Cilazapril
  • Dipyrone
  • Enalapril
  • Etoricoxib
  • Floctafenine
  • Ginkgo
  • Gossypol
  • Indomethacin
  • Ketorolac
  • Lisinopril
  • Meclofenamate
  • Metildigoxin
  • Nimesulide
  • Phenelzine
  • Prazosin
  • Saxagliptin
  • Urapidil
  • Valdecoxib
  • Zofenopril

However, in cases where treatment is necessary with these drugs, your physician can adjust the dosage of either or both medications.

Consuming green tea while using the Nadolol and Bendroflumethiazide combination is not recommended because it can cause adverse reactions. Talk to your physician about alcohol consumption and tobacco use when on this medication. Other medical problems may also have negative effects while taking this combination drugs.

Inform your doctor if you have:

3 Proper Usage

Aside from using Nadolol and Bendroflumethiazide, treatment of hypertension involves making lifestyle changes as well. If you are overweight, it is necessary to lose those extra pounds. You also need to have a low sodium diet. Ask your physician about the necessary weight control and diet changes.

Symptoms of high blood pressure are usually not overtly manifested. That is why it’s important to take the nadolol and bendroflumethiazide medication according to your doctor’s orders. Do not take more or less of it, and do not stop taking it even if you feel better.

Inform your physician if you want to stop taking this medicine. Abruptly stopping it can cause serious effects.

Dosing is individualized. However, normal dosing for adults is one tablet a day. This can be adjusted by your healthcare professional. The doctor will be determined the dose for children. If you forget to drink a dose, take it as soon as possible. But if the next timing is close, skip it and resume the regular schedule.

Store this medication at room temperature and away from children.

4 Precautions To Take

Always keep your appointments with your physician so that your condition can be monitored closely. There are precautions you need to take when you are taking this medication.

Watch out for signs of heart failure which include but are not limited to chest pain, dilated neck veins, irregular heartbeat, weight gain, swelling (fingers, face, legs, and feet), and wheezing.

If you have diabetes, keep monitoring your sugar levels because the Nadolol and Bendroflumethiazide combination can mask low blood sugar. Inform your other physicians and your dentist that you are using this medication before getting any surgery or dental treatment.

5 Potential Side Effects

 There are several side effects that you need to watch out for. Some go away without treatment while others need immediate medical attentions. Call your doctor right away if you experience:

  • Blurred vision
  • Numbness
  • Chest pain
  • Difficulty breathing
  • Dilated neck veins,
  • Paleness or Cold feeling in fingertips and toes
  • Slurred speech
  • Weight gain

Get medical attention immediately if you have symptoms of overdose, which include:

  • Change in consciousness
  • Decreased urination
  • Diarrhea
  • Heartburn
  • Increased sweating
  • Low blood pressure
  • Cyanosis
  • Seizures
  • Weakness and Heaviness of legs
  • Wrinkled skin

This is not a complete list, so talk to your physician for further information.

The following effects may not need treatment but call your doctor if they become bothersome or do not improve:

Again, talk with your doctor if you have any concerns.

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