1 What is Danocrine?

Brand: Danocrine

Generic: Danazol

Brand name:


Danazol, a synthetic steroid, is indicated for the treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema.

It is also used to treat gynecomastia, menorrhagia, and precocious puberty in females. You can only buy danazol if you have a doctor’s prescription.

It is sold as a capsule. It is derived from ethisterone, which is a weak a weak progestogen.

2 What to Know Before Using

You and your physician need to talk about the risks and benefits associated with danazol use before starting treatment. Individuals who have had hypersensitivity reactions to danazol should not be given Danocrine.

Also, you need to tell your healthcare provider if you have allergies to animals, food, preservatives, and other medicines. Not enough research into the safety and efficacy of danazol in pediatric patients has been done.

There have been no documented specific problems in the geriatric population related to danazol use. This medicine should not be given to pregnant women as it can cause fetal abnormalities.

Make sure you are not pregnant before you take this medication and do not get pregnant while taking it. If you do become pregnant during treatment, inform your physician right away.

Danazol is not recommended for breastfeeding since it is not clear if it came be passed in breast milk and cause harm to the infant. Other medications can interact with danazol and cause harm to the patient.

Make sure your physician has a list of all your medications. Your doctor may choose not to treat you with danazol if you are currently taking simvastatin.

Concomitant use of the following is not normally recommended but can be necessary: anisindione, atorvastatin, bupropion, dicumarol, fluvastatin, lovastatin, and phenprocoumon.

If you are also taking carbamazepine, cyclosporine, tacrolimus, or warfarin, you might experience certain side effects. Ask your doctor if you need to avoid specific foods, beverages or other substances like tobacco and alcohol.

Individuals who have Abnormal vaginal bleeding, history of blood clots, heart disease, kidney disease, liver disease or, porphyria, or androgen-dependent tumors should not be given danazol.

This medicine can also worsen the following conditions: diabetes, epilepsy, fluid retention, edema, heart failure, hypertension, kidney failure, migraine headaches, and polycythemia.

Inform your physician if you have the aforementioned conditions.

3 Proper Usage

Take danazol as prescribed by your treating physician. Do not change your dose, schedule or treatment duration without consulting him/her first. Doing so may result in harm.

You should begin treatment during your menstrual period and take it at the same time of the day. The dose and timing of danazol depend on the condition being treated.

For mild endometriosis, adults may take 200 to 400 mg in 2 doses for up to 9 months. For moderate to severe endometriosis, adults may need 800 mg divided into 2 doses, daily, for up to 9 months.

Patients with fibrocystic breast disease should take 100-400 mg divided by 2 doses daily. Dose adjustments will be done by your doctor. For hereditary angioedema prevention, adults should take 200 mg twice or thrice daily.

Unless it’s almost time for the next dose, you should take a missed dose as soon as you remember. Danazol should be stored at room temperature and away from children’s reach. Throw away expired medications.

4 Precautions to Take

To make sure that danazol is working well for you, your doctor needs to monitor your condition closely. This means that you need to go to regular follow-up appointments.

You may also need to have multiple blood tests done. You also need to take special measures so that you don’t experience adverse reactions. As mentioned earlier, danazol can cause harm to the unborn child and you should avoid getting pregnant.

You effective birth control methods aside from contraceptive pills like condoms, diaphragms, or spermicides. Danazol can also cause menstrual irregularities.

If you do not get your period 60-90 days after treatment, you should contact your doctor as soon as possible. Stop using danazol if you start having blurred vision, changes in the ability to see colors, headaches, nausea, or vomiting.

Diabetic patients need to regularly monitor their sugar levels and report any unusual change. This medicine can also increase your skin’s sensitivity to sunlight although cases are rare.

Consult your physician before you take new medications.

5 Potential Side Effects

Danazol can cause different side effects for males and females.

However, both male and female may experience acne, increased oiliness of the hair or skin, dark-colored urine, muscle spasms, rapid weight gain, swelling of the lower limbs, and unusual tiredness.

Side effects that only appear in females include a decrease in the breast size, weight gain, and irregular menstrual periods.

Males may experience changes in semen and a decrease in the size of the testicles. Check with your physician right away if you experience any of those symptoms.