1 What is Desyrel?

Brand: Desyrel

Generic: Trazodone Hydrochloride


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Desyrel may interact with medications such as:

  • Sibutramine
  • Other antidepressants such as amitriptyline, bupropion, fluoxetine, nefazodone or venlafaxine
  • Digoxin
  • Azole antifungals including ketoconazole or itraconazole
  • HIV protease inhibitor drugs including atazanavir, indinavir or ritonavir
  • Macrolide antibiotics including erythromycin
  • Cimetidine
  • Rifamycins including rifampin
  • St. John's wort
  • Certain anti-seizure medications including carbamazepine
  • Drugs for high blood pressure
  • Ginkgo
  • MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
  • Certain antihistamines (diphenhydramine)
  • Anti-seizure drugs (phenytoin)
  • Medicine for sleep or anxiety such as alprazolam, diazepam or zolpidem
  • Muscle relaxants
  • Narcotic pain relievers such as codeine
  • Psychiatric medicines such as chlorpromazine or risperidone

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following: