1 Doxylamine And Pyridoxine (Oral Route): A Summary

Brand: Diclegis

Generic: Doxylamine And Pyridoxine (Oral Route)

Brand name:


Doxylamine (antihistamine) and pyridoxine (vitamin B6) combination are used for the treatment of nausea and vomiting in pregnant women whose symptoms have not been relieved by other therapies. This drug requires a prescription.

2 What to Know Before Using

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children regarding the relationship of age to the effects of doxylamine and pyridoxine combination have not been performed while safety and efficacy have not been established.

Data on the relationship of age to the effects of doxylamine and pyridoxine combination in geriatric patients are still unavailable. Increased risks of fetal abnormalities have not been reported in studies of pregnant women.

Infant risk is still undetermined when using this drug during breastfeeding. Discuss with your healthcare professional about the potential risks and benefits of taking this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as:

  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Methylene Blue
  • Moclobemide
  • Pargyline
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Selegiline
  • Sodium Oxybate
  • Tranylcypromine
  • Altretamine
  • Bromazepam
  • Buprenorphine
  • Bupropion
  • Carbinoxamine
  • Donepezil
  • Fentanyl
  • Flibanserin
  • Hydrocodone
  • Hydromorphone
  • Meclizine
  • Methadone
  • Morphine
  • Morphine Sulfate Liposome
  • Oxycodone
  • Oxymorphone
  • Suvorexant
  • Tapentadol
  • Zolpidem

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as asthma, bladder blockage, bowel blockage, glaucoma, or peptic ulcer.

3 Proper Usage

To prevent any side effects, take this drug exactly as directed on the label or as prescribed by your healthcare professional. The dose of this drug will be variable for different patients.

The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

Adults with nausea and vomiting during pregnancy must take two tablets taken at bedtime. If symptoms are controlled the following day, continue taking two tablets at bedtime.

If symptoms persist in the afternoon of Day 2, take two tablets at bedtime and start taking three tablets on Day 3. If symptoms are controlled on Day 4, continue taking three tablets daily.

Otherwise, take one tablet in the morning, one tablet in the mid-afternoon, and two tablets at bedtime. Use and dose in children must be determined by your healthcare professional.

A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug.

Report any unwanted or unusual effects to your healthcare professional.

Avoid the necessary medications and activities that are advised against you to prevent unwanted effects.

Check with your healthcare professional before you take any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • chest discomfort
  • a decrease in the frequency of urination
  • a decrease in urine volume
  • difficult or labored breathing
  • difficult or painful urination
  • fast, irregular, pounding or racing heartbeat or pulse
  • swelling of the eyelids, face, lips, hands or feet

Some side effects may occur that usually do not need medical attention. As your body adjusts to the drug, the side effects will slowly disappear.

Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

Report any side effects to the FDA hotline at 1-800-FDA-1088.

6 Related Clinical Trials