1 What is Differin?

Brand: Differin

Generic: Adapalene

Brand name:


Differin is a skin treatment used in the treatment of acne vulgaris. This drug is available as a gel containing either 0.1% or 0.3% of adapalene. It is also available as a lotion containing 0.1 % of adapalene.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also use this drug at the same time each day.

This drug is to be applied to the skin only. Avoid using it in the face, groin, or underarms, or for diaper rash, unless told so by your doctor.

First, wash and dry your hand before applying. The affected area should be cleansed and dried. The medication should be applied as a thin film to be gently rubbed in, as instructed by your doctor. Avoid covering or wrapping the treated area. Wash your hands after use. Avoid contact with eyes, mouth or mucous membranes. If contact occurs, rinse with plenty of water.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Differin may interact with medications such as:

  • Products containing alpha hydroxy acids
  • Products containing glycolic acid
  • Hair perming solutions
  • Alcohol/lime/menthol-containing products such as astringents, toners and shaving lotions
  • Medicated or abrasive soaps and cleansers
  • Products containing sulfur
  • Resorcinol or salicylic acid
  • Soaps and cosmetics with a strong drying effect
  • Other drugs that may increase your sensitivity to sunlight such as fluoroquinolones (ciprofloxacin), tetracyclines, thiazide water pills such as hydrochlorothiazide, sulfa drugs such as sulfamethoxazole, and phenothiazines such as chlorpromazine

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to adapalene
  • Eczema
  • Pregnancy or lactation

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