Duo-Vil 2-10

1 What is Duo-Vil 2-10?

Brand: Duo-Vil 2-10, Duo-Vil 2-25, Etrafon

Generic: Perphenazine and amitriptyline

Brand name:

Duo-Vil 2-10, Duo-Vil 2-25, Etrafon.

Perphenazine and amitriptyline combination is used for the management of both mental and emotional conditions of the body. These medicines are only available with the doctor's prescription.

2 What to Know Before Using

The decision to use this medicine needs to be weighed against the good the medicines can do. This decision is reached by the consultation of both you and your doctor. At this time, inform your doctor if you have any form of allergic reactions to this medicines or any other form of medicines. In addition, inform your doctor if you have any form of allergies to food, dyes, preservatives or animals and their products.

In the case of nonprescription drugs, reads the label or package to evaluate the ingredients carefully. This medicine may induce certain side effects in the pediatrics such as muscles spasms of the face, neck, back, tac like or twitching movements, inability to move the eyes, twisting of the body, or weakness of the arms and legs, are more likely to occur.

The children are more sensitive than adults to some of the side effects of the perphenasine and amitriptyline combination. The combination of the drugs needs to be used with caution when used on children suffering from depression. It has been demonstrated to promote suicidal thinking in children or attempted suicides in clinical trials subjects using this drugs in combination.

More studies are required to understand the safety and efficary of the combination of perphenazine and amitriptylinein children. On the other hand, geriatric signs of confusion, vision problems, dizziness or fainting, drowsiness, dryness of mouth, constipation, problems in urinating, trembling of the hands and fingers, and symptoms of tardive dyskinesia (such as uncontrolled movements of the mouth, tongue, jaw, arms, and/or legs) are especially likely to occur. It is known that older patients are more sensitive than younger adults to the effects of combined perphenazine and amitriptyline.

Moreover, findings on the effect of the combination of perphenazine and amitriptyline on breastfeeding are inadequate and inconclusive; the risk of infants when breast feeding from mothers using this medication has not been established. It is necessary to weigh the potential benefits against the risks before using this medication while breast feeding. Despite the facts that certain medications need not be used together at all. Certain medicines may still be used even with the risk of a possible interaction.

However, the doctors may change or vary the dosages used and take precautions as may be required. First, inform your doctor all the medicines that you are using. Then take note if you are using any of the medicines that are listed below.  The medicines listed are known and selected on the basis of the potential significance and not just on aspects of all-inclusiveness.

Use of the combination of perphenazine and amitriptyline with any of these medicines is not allowed.  Your personal doctor may however decide on how to use the medicine or not or change some of the medications you take.  This medications include:

  • Amifampridine
  • Bepridil
  • Cisapride
  • Clorgyline
  • Dronedarone
  • Droperidol
  • Furazolidone
  • Grepafloxacin
  • Iproniazid
  • Isocarboxazid
  • Levomethadyl
  • Linezolid
  • Mesoridazine
  • Methylene Blue
  • Metoclopramide
  • Moclobemide
  • Nialamide
  • Pargyline
  • Phenelzine
  • Pimozide
  • Piperaquine
  • Procarbazine
  • Ranolazine
  • Safinamide
  • Saquinavir
  • Selegiline
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Toloxatone
  • Tranylcypromine
  • Ziprasidone

Use of this medicine with the combinational of perphenazine and amitriptyline  is not allowed. They may be needs in some cases. When they are prescribed together though, the dosage will be changed or how often you take the medicine or both of the medicines.

  • Acecainide
  • Aceclofenac
  • Acemetacin
  • Albuterol
  • Alfuzosin
  • Almotriptan
  • Amiodarone
  • Amisulpride
  • Amoxapine
  • Amtolmetin
  • Guacil
  • Anagrelide
  • Apomorphine
  • Aprindine
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Aspirin
  • Astemizole
  • Atazanavir
  • Azimilide
  • Azithromycin
  • Bretylium
  • Bromazepam
  • Bromfenac
  • Brompheniramine
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Buspirone
  • Celecoxib
  • Chloral Hydrate
  • Chloroquine
  • Chlorpheniramine
  • Chlorpromazine
  • Choline Salicylate
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clonidine
  • Clonixin
  • Clozapine
  • Cocaine
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Dextromethorphan
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxorubicin
  • Doxorubicin
  • Hydrochloride
  • Liposome
  • Droperidol
  • Droxicam
  • Eletriptan
  • Eliglustat
  • Enflurane
  • Epinephrine
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Etilefrine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Foscarnet
  • Frovatriptan
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydrocodone
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxytryptophan
  • Ibuprofen
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indomethacin
  • Iobenguane I 123
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lacosamide
  • Lapatinib
  • Leuprolide
  • Levalbuterol
  • Levofloxacin
  • Levomilnacipran
  • Levorphanol
  • Levothyroxine
  • Lidoflazine
  • Lithium
  • Lopinavir
  • Lorcainide
  • Lorcaserin
  • Lornoxicam
  • Loxoprofen
  • Lumefantrine
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Meperidine
  • Methadone
  • Methoxamine
  • Metrizamide
  • Metronidazole
  • Midodrine
  • Milnacipran
  • Mirtazapine
  • Moricizine
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nabumetone
  • Nafarelin
  • Naproxen
  • Naratriptan
  • Nefazodone
  • Nefopam
  • Nepafenac
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Norepinephrine
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Oxaprozin
  • Oxilofrine
  • Oxycodone
  • Oxymorphone
  • Oxyphenbutazone
  • Paliperidone
  • Palonosetron
  • Panobinostat
  • Parecoxib
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pentamidine
  • Pentazocine
  • Perflutren Lipid Microsphere
  • Phenylbutazone
  • Phenylephrine
  • Piketoprofen
  • Piroxicam
  • Pixantrone
  • Posaconazole
  • Pranoprofen
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Proglumetacin
  • Promethazine
  • Propafenone
  • Propoxyphene
  • Propyphenazone
  • Proquazone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Rasagiline
  • Risperidone
  • Rizatriptan
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Sodium Salicylate
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sulindac
  • Sultopride
  • Sumatriptan
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tenoxicam
  • Tetrabenazine
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Toremifene
  • Tramadol
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Tryptophan
  • Valdecoxib
  • Vandetanib
  • Vardenafil
  • Vasopressin
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vilazodone
  • Vinflunine
  • Voriconazole
  • Vortioxetine
  • Zolmitriptan
  • Zotepine

Use of a combination of perphenazine and amitriptyline  with some of the medicines that are listed below may cause an increased risk of cetain side effects. However, using both drugs may provide the best medical option for certain medical conditions. In case the medicines are prescribed together, your doctor may change the dose or how frequently they can be administered or both medicines. They include:

  • Acenocoumarol
  • Arbutamine
  • Atomoxetine
  • Belladonna
  • Belladonna Alkaloids
  • Betel Nut
  • Bethanidine
  • Carbamazepine
  • Cimetidine
  • Diazepam
  • Dicumarol
  • Evening Primrose
  • Fluvoxamine
  • Fosphenytoin
  • Galantamine
  • Guanethidine
  • Meperidine
  • Midodrine
  • Orphenadrine
  • Paroxetine
  • Phenprocoumon
  • Phenylalanine
  • Phenytoin
  • Procyclidine
  • Rifapentine
  • Ritonavir S-Adenosylmethionine
  • St John's Wort
  • Topiramate
  • Trihexyphenidyl
  • Warfarin

It is possible that these medicines may also have other forms of interactions when using these medicines at or around the time of eating food or other types of foods. Moreover, using alcohol together with tobacco with certain medicine may cause interactions to occur. The interactions are selected on the basis of their potential significance.

It is not advisable to use this medicines with the combined doses of perphenazine and amitriptyline. It can be used however in certain situations and when used together, he doctor may vary the times, doses and frequency of administration of the drugs. Special instructions may be provided when use of food, alcohol or tobacco have to be used. This may increase the risk or certain side effects but may be unavoidable in some cases.

Presence of other medical problems may affect the use of this medicines. It is advisable that your doctor has knowledge of use of this medicines in case of any medical problems especially with respect to alcohol abuse. Certain side effects such as heat stroke, Asthma may occur, lung diseases or bipolar disorders (manic depressive illness or blood disease or breast cancer, difficulty in urination, enlarged prostate or epilepsy or seizure disorders or glaucoma or heart or blood vessel disease or mental illness or Parkinson’s disease or stomach or intestinal problems needs to be reported.

The combined therapy with perphenazine and amitriptyline may make the kidney or liver conditions worse.  Very high blood levels of perphenazine and amitriptyline may increase the heart of the Reye’s syndrome increase. Other unwanted effects may be increased in the liver.

3 Proper Usage

To reduce the stomach upset, this medicine needs to be taken immediately after the meals or food. This must be done in accordance with the doctor’s instructions. It is advisable not take more of this medicines than prescribed by your medical doctor. This is especially important for elderly patients due to their sensitivity to the effects of medicines. In some cases, the effects of perphenazine and amitriptyline combination can be felt after a full week of using the medicine.

The dose of this medicine will vary from one patient to another. It is advisable to follow the instruction so the doctor. Also, read the instructions that come with the medicine before using the drug. If the dose is different, never change the dose unless advised by your doctor.

The amount of the medicine also depends on the strength of the medicine. This also determines the number of doses you take each day, time allowed between doses, length of time you take, and the medical problem for which the medicine is being used. In case of the oral dosage form of tablets in the management of mental or emotional conditions:

  • Adults, need to take 1 tablet three times a day. The dose may be increased when needed.
  • As for the children, the dose to be administered will be determined by the medical doctor.

In case of missed doses, take the medicine as soon as possible. But when it is almost the time for the next dose, skip the dose and resume the regular schedule for the dose. Never double the dose at a time. The medicine needs to be stored in a closed container and at room temperature, away from heat, moisture and from direct sunlight.

Keep the medicine from freezing and out of reach of children. Never store outdated medicine or medicine that is not usable.

4 Precautions to Take

Regular progress needs to be checked with regular visits so as to evaluate the effectiveness and safety of the dose. This will also allow for the adjustment of the doses at the regular visits so as to help adjust the side effects. Never stop using these medicines without consulting your medical doctor. The doctor can reduce taking the medicine gradually until when the medicine can be stopped completely. This will be done so as to reduce the side effects and to prevent the condition of becoming worse.

It is advisable that this medicine should not be used within 2 hours of taking antacids or medicine for diarrhea. Using these medicines closely together will reduce the effectiveness of these medicines. It is also known that this medicine can add to the effect of alcohol or CNS depressants such as:

  • Antihistamines or hay fever drugs
  • Drugs for allergies, cold, sedatives, tranquilizers, pain or narcotics, barbiturates, seizures or anesthetics

It is recommended that one needs to check with their doctor before taking any of the above medicines. Similarly, before any form of surgery, dental treatment, or emergency treatment, always inform your doctor that you are using these medicines. A combination of perphenazine and amitriptyline together with medicines used during surgery increase the CNS depressive effects. This may also cause some of the people to become agitated, irritable or display abnormal behaviors.

It causes some people to have suicidal thoughts, tendencies or become more depressed. This signs needs to be reported to the doctor right away. It also causes drowsiness, lack of alertness, in the first few weeks of treatment.  Even when consumed at bedtime, it will cause drowsiness in some people making them to become less alert on arising.  It is important to understand how you react when using this medicine, use machines or do anything else since it can be very dangerous.

One may feel dizziness, lightheadedness, fainting etc when waking up from a sitting or lying position. It is advisable to get up slowly and when the problem gets worse, check with your medical doctor. This medicine may also induce you to sweat less.  They sometimes cause body temperatures to increase. It is advisable to use extra care when one become over heated especially when doing exercise or in hot weather after using this medicine which can result to heat stroke.

Using a hot bath or saunas, will make one to feel dizzy or even faint. perphenazine and amitriptyline combined can be used to cause dryness of the mouth. It is advisable to use sugarless gum, candy, melt bits of ice in the mouth, saliva substitute for temporal relief. However, when the mouth continues to feel dry for more than 2 weeks, consult your medical doctor or dentist. Continued dryness of the mouth may increase the chances of contracting a dental disease such as tooth decay, gum disease or fungus infections. Perphenazine may make the skin more sensitive to sunlight that when normal.

Exposure to sunlight even at brief periods of time may cause one to develop skin rash, itching, redness or other forms of discoloration of the skin or severe sunburn. When using this medicine, it is advisable to stay away from direct sun light which becomes more intense between 10.00 am and 3.00 pm. When possible, put on protective clothing such as a hat and sun glasses. Use a sun block product which has a skin protecting factor of about 15.

Some of the patients require products that have a higher SPF number and more especially when they have a fair complexion. If you have any questions, ask your doctor. Similarly, use a sun blocker lipstick that has an SPF of at least 15 to protect your lips. Never use sun lamps or tanning bed or booth. If you have a severe reaction from the sun, check with your medical doctor.

5 Potential Side Effects

Besides the effects that are needed when using the medicines, perphenazine, which can be sometimes can cause serious side effects. Tardine dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardine dyskinesia include:

  • Fine, worm like movements of the tongue
  • Other uncontrolled movements of the mouth, tongue, cheeks, jaws or arms and legs

There are other serious side effect such as:

  • Muscle stiffness
  • Fever
  • Unusual tiredness
  • Weakness
  • Fast heartbeat
  • Difficult breathing
  • Increased sweating
  • Loss of bladder
  • Unusual tiredness or weakness
  • Fast heartbeat
  • Difficulty in breathing
  • Increased sweating
  • Loss of bladder control
  • Seizures

It is important to evaluate the good the medicine will do you as well as the risk of exposure to the medicine. Stop using the medicine and seek emergency help in case of side effects.

Rare side effects consists of:

  • Convulsions
  • Difficulty in breathing as a result of fast heartbeat
  • Fever
  • High or Low blood pressure
  • Increased sweating
  • Loss of bladder control
  • Muscle stiffness
  • Unusual tiredness or weakness
  • Pale skin

Check with your doctor as soon as possible when any of the following side effects occur.

Common side effects include:

  • Blurred vision
  • Change in vision
  • Difficulty in speaking, swallowing
  • Fainting
  • Inability to move eye lids, smacking or puckering
  • Loss of balance control
  • Mask-like face
  • Muscle spasms, especially of face, neck, and back
  • Nervousness
  • Restlessness, or need to keep moving puffing of cheeks
  • Rapid or fine, worm-like movements of tongue
  • Shuffling walk
  • Stiffness of arms and legs
  • Trembling and Shaking of fingers and hands
  • Tic-like or twitching movements
  • Twisting movements of body
  • Uncontrolled chewing movements
  • Uncontrolled movements of arms or legs
  • Weakness of arms and legs

Less common symptoms present as:


  • Abdominal or Stomach pain
  • Aching muscles or joints back or leg pain
  • Fever and Chills
  • Hair loss
  • Hot, Dry skin or lack of sweating
  • Irritability
  • Loss of appetite
  • Muscle weakness or twitching
  • Nausea, Vomiting, or Diarrhea
  • Nosebleeds
  • Prolonged, Painful, Inappropriate penile erection
  • Ringing, Buzzing, or other unexplained noises in ears
  • Skin discoloration
  • Skin rash and itching
  • Sore throat and fever
  • Swelling of face and tongue
  • Swelling of testicles
  • Unusual bleeding or bruising
  • Yellow eyes or skin

In case of an overdose,  symptoms will include

  • Agitation
  • Confusion
  • Convulsions (seizures)
  • Drowsiness (severe)
  • Enlarged pupils
  • Fast, Slow, or Irregular heartbeat
  • Fever hallucinations (seeing, hearing, or feeling things that are not there)
  • Shortness of breath or troubled breathing
  • Unusual tiredness or weakness (severe)
  • Vomiting (severe)

In some cases, some of the medical symptoms may occur and will not need medical attention. This is because the side effects may go away when the body adjusts to treatment. Your doctor can also advise you on way of reducing the side effects of the medicine. Always check with your healthcare professional in case of these side effects and more especially when they become bothersome or have questions about them.  It is recommended to stop using the medicine if side effects require serious medical attention.

Also, check with your doctor immediately if you notice other side effects. Other side effects may not be listed for some patients. When some of the side effects occur, check with your healthcare professionals. Call your doctor for medical advice about side effects. Report the side effects to FDA at 1-800-FDA-1088.

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