1 What is Duraclon?

Brand: Duraclon

Generic: Clonidine

Brand Name:


Clonidine injection is a centrally acting alpha-antagonist hypotensive agents used with injected analgesics to treat cancer-induced pain. 

Clonidine is to be given only under the immediate supervision of your healthcare professional. This drug can be taken at home only with the advice of your healthcare professional. 

Off-label use of this drug can be for treatment of post-operative shivering. This drug requires a prescription.

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2 What to Know Before Using

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. 

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. There are no specific data comparing use of clonidine in children and elderly with use in other age groups, this drug is not expected to cause any different side effects or problems in children than it does in adults. 

The use of this drug in children is recommended only when other drugs are ineffective in treating severe and other types of pain. It is still unknown whether these drugs work exactly the same way in younger adults or if they cause different side effects or problems in the elderly. 

Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. This drug may alter milk production or composition. Monitor you infant for side effects and adequate milk intake if an alternative to this drug is not prescribed. 

Discuss with your healthcare professional the possible risks and benefits before taking this drug while breastfeeding. Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects. 

Inform your healthcare professional if you are taking any other drugs such as Amifampridine, Acebutolol ,Amitriptyline, Amoxapine, Atenolol, Betaxolol, Bevantolol, Bisoprolol, Carteolol, Celiprolol, Clomipramine, Crizotinib, Desipramine, Dilevalol, Diltiazem, Dothiepin, Doxepin, Esmolol, Imipramine, Levobunolol, Lofepramine, Metipranolol, Metoprolol, Mirtazapine, Nadolol, Nebivolol, Nortriptyline, Oxprenolol, Penbutolol, Pindolol, Propranolol, Protriptyline, Sotalol, Tertatolol, Timolol, Trimipramine, Verapamil, Cyclosporine, Fluphenazine, Mepivacaine, Naloxone, or Yohimbine

Intake of specific food or using alcohol or tobacco with magnesium is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. 

Inform your healthcare provider for any other medical problems such as bleeding, cardiovascular, kidney disease, pain associated with surgery, or pain during or following childbirth.

3 Proper Usage

This drug is given continuously as an epidural infusion using an infusion pump to the spinal cord. The pump and its tube, injection or catheter site should be checked regularly for signs of accidental stoppage of flow, or any infection. 

Consult with your healthcare professional for proper usage of this drug. The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed. 

The dosage of this drug you take depends on the medical problem for which you are using this drug. Adults with pain are given 30 mcg per hour given as a continuous infusion. Dosage in children is based on body weight and must be determined by your healthcare professional. 

Consult with your healthcare professional immediately if you missed a dose or if you think the clonidine has stopped for any reason. Store this drug in a closed container at room temperature, away from heat, moisture, and direct light. 

Keep from freezing. Keep out of the reach of children. Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

Serious side effects may occur if clonidine is stopped abruptly. Consult with your healthcare professional before you stop taking this drug. This drug may potentiate the effects of alcohol and other CNS depressants. 

Dizziness, light-headedness, or fainting may occur, especially when you get up from a lying or sitting position may occur if you take this drug with alcohol or other depressants. 

This may cause you to be drowsy or less alert than normally and be careful in taking this drug before you drive, use machines, or do other jobs that require you to be alert.

5 Potential Side Effects

Side effects may vary for each individual and prompt medical attention should be given if they occur. 

Inform you healthcare provider immediately if you experience any unusual symptoms such as:

Some side effects may occur that usually do not need medical attention. These side effects will eventually disappear as your body adjusts to the drug. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

 If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. 

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.