1 What is Edecrin?

Brand: Edecrin

Generic: Ethacrynic Acid

Edecrin is classified as a loop diuretic or "water pills." Ethacrynic acid is administered so as to help in the management of fluid retention (edema) and swelling that is often caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. The medicine works on the kidneys so as to increase the flow of urine. This drug is also available only with the prescription of the medical doctor.

2 What to Know Before Using

Before Edecrin can be used, the risk of using this medicine needs to be weighed against the good will of using this medicine. This is the decision that must be reached by you and your doctor. There also several other factors that must be considered. In case of allergies, inform your medical doctors. If you have ever had unusual or allergic reactions to this medicine or any other medicines. You are also required to inform your medical doctor if you have any other form of allergies to food, dyes, preservatives or animals.

When using non-prescription products, read the label or package of the ingredients before you can use them. Before using this medicines on the pediatrics, check on pediatric studies on the use of this medicines. Appropriate studies have not been performed on the relationship of age to the effects of Ethacrynic acid in the pediatric population. Moreover, safety and efficacy studies of the children have also not been performed. Similarly, geriatric studies performed to date have not shown geriatric specific problems that limit the use of Ethacrynic acid in the elderly.

In case of pregnancy in women, Ethacrynic acid animal studies have shown adverse effects and there are no adequate studies in pregnant women. In addition, no animal studies have been done and there are no adequate studies that have been conducted and the studies conducted to date are not adequate in pregnant women.

In breastfeeding mother, there are no adequate studies in women for determining the infant risk when using this medication while breastfeeding. It is important to weigh the significant potential for risks before using this medication while breastfeeding. As for the drug interactions, some of the medicines may not be used together completely. In other cases, these medicines may also be used together even with the potential of a significant interactions occurring.

In such like cases, the doctor may need to change the dose or other precautions as may be necessary. It is important to let know your doctor when using this medicines. The following interactions have also been selected on the basis of their potential significance and are never inclusive. Use of these medicines is often not recommended. 

However, it may be required in some cases. But when both of the medicines are required in some of the cases, both medicines may be prescribed together. The doctor may change the dose or the frequency with which you take the medicine or both medicines. Some this medicine includes:

  • Amikacin
  • Arsenic Trioxide
  • Bepridil
  • Digitoxin
  • Dofetilide
  • Droperidol
  • Foscarnet
  • Furosemide
  • Gentamicin
  • Kanamycin
  • Ketanserin
  • Levomethadyl
  • Lithium Metolazone
  • Neomycin
  • Netilmicin
  • Sotalol Streptomycin
  • Tobramycin

In addition, use of this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. They include:

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Amtolmetin Guacil
  • Aspirin
  • Benazepril
  • Bromfenac
  • Bufexamac
  • Captopril
  • Celecoxib
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Cortisone
  • Delapril
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Enalapril
  • Enalaprilat
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Germanium
  • Ginseng
  • Gossypol Ibuprofen
  • Ibuprofen Lysine
  • Imidapril
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Proglumetacin
  • Propionic Acid
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Ramipril
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Spirapril
  • Sulindac
  • Temocapril
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Trandolapril
  • Valdecoxib
  • Zofenopril

Other interactions may occur when the medicine is used at or around times of eating food, or eating certain types of foods. Moreover, using alcohol or tobacco may cause other interactions to occur. You may also need to discuss with your healthcare professional on the use of this medicine with food, alcohol or tobacco.

Other medical problems may be present and may interfere with the use of these medicines. Inform your medical doctor if you have any other medical problems especially such as anuria or electrolyte imbalance, severe or watery diarrhea. In severe cases, one should not use these medicines in patients. In cases of diabetes, this medicine must not be used, it can caused in increase in the levels of sugar in blood.

Sometimes, it is associated with hearing problems or hypochloremia (low chloride in blood) or hypokalemia (low potassium in the blood. It also causes hypomagnesemia (low levels of magnesium) or hyponatremia (low sodium in blood) or hypovolemia (low blood volume) or liver diseases (cirrhosis), and advanced conditions of liver diseases.

Use these medicines with cautions. Use of these medicines may make these conditions worse. Hypoproteinemia (low protein in the blood) may decrease the effects of the medicines in the body. In conditions of kidney diseases, or severe cases, use these medicines with caution. The effects of this medicine may be increased as a result of the slow removal of the medicines from the body.

3 Proper Usage

Edecrin needs to be used after meals. Often, the dose of this medicine will often be different patients. It is important that the doctor orders or directions on the labels. The information provided in this article includes only average doses of these medicines. When the dose provided is different, never change the dose unless your doctor informs you to do so. The amount of the medicines that you take depends on the strengths of the medicines.

In addition, the amount of medicines that you take relies on the strength of the medicines. Moreover, the number of the doses you take each day, the time allowed between doses and the length of time you take the medicine which depends on the medical problems for which the medicine is being consumed. When using the oral dosage, for management of edema in adults, a first dose of 50 milligrams (mg) once a day is recommended. Your doctor may also adjust your dose when required. Children that are aged 2 to 18 years of age will first received a dose of 25 milligrams (mg) one a day. Your doctor may adjust your dose if needed. Children below 2 years of age will have a dose which will be determined by your doctor.

In case of missed doses, take it as soon as possible. However, when it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Never take double doses. The medicine also need to be stored  in a closed container at room temperature and away from heat moisture and direct light. Keep the drugs from freezing.

Also, keep them out of reach of children. Never store outdated medicines or medicines that are no longer required. Consult your healthcare professional on how to dispose any of the medicines that you do not use.

4 Precautions to Take

In using Edecrin, you must be careful and take some precautions as advised by your doctor.

Regular medical checkup is required during the regular visits at the hospital to ensure that the medicine is working properly. Blood tests may also be used for the analysis of unwanted effects. You will also need to weight yourself daily and record your weight. The medicine may also cause you to lose more potassium from your body than normal. Your doctor will also monitor the potassium in your blood while you are taking this medicine.

To prevent the loss of too much water and potassium, inform your doctor when you become sick with severe or continuing nausea, vomiting or diarrhea. In case of more symptoms, check with your doctor right away. The symptoms include:

The medicine may also cause changes in the blood sugar levels. When there is a change in the results of the blood or urine sugar tests. In case of any questions, check with your doctor.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Edecrin.

Always check with your medical doctor immediately when any of the side effects occur. The side effects may be rare and include:

  • Bleeding gums
  • Bloating
  • Clay-colored stools
  • Constipation
  • Darkened urine
  • Indigestion
  • Itching large
  • Flat, Blue or Purplish patches in the skin
  • Loss of appetite
  • Nausea
  • Painful knees and ankles
  • Pains in stomach, side, or abdomen, possibly radiating to the back
  • Pinpoint red spots on skin
  • Raised red swellings on the skin, the buttocks, legs, or ankles
  • Skin rash
  • Unpleasant breath odor
  • Vomiting of blood
  • Yellow eyes or skin

Some of the incidence are not determined  such as:

  • Anxiety
  • Black, tarry stools
  • Blood in urine
  • Blurred vision
  • Cold sweats
  • Coma
  • Confusion
  • Convulsions (seizures)
  • Cool, Pale skin
  • Cough or Hoarseness
  • Depression
  • Dizziness
  • Dry mouth
  • Fast heartbeat
  • Fever with or without chills
  • Flushed, dry skin fruit-like breath odor
  • General feeling of tiredness or weakness
  • Headache
  • Increased hunger
  • Increased thirst
  • Increased urination
  • Joint pain, stiffness, or swelling lower back, side, or stomach pain
  • Nausea
  • Nervousness
  • Nightmares
  • Painful or Difficult urination
  • Pale skin
  • Shakiness
  • Shortness of breath
  • Slurred speech
  • Sore throat
  • Sores, ulcers, or white spots on the lips or in the mouth
  • Sweating
  • Swelling of the feet or lower legs
  • Troubled breathing
  • Unexplained weight loss
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Vomiting
  • Watery and Severe diarrhea

It is important to get emergency help immediately when any of the following symptoms of overdose occur:

  • Symptoms of overdose include:
    • Confusion
    • Decreased urination
    • Dizziness, Faintness, or Lightheadedness, when getting up from a lying or sitting position suddenly
    • Increase in heart rate
    • Irregular heartbeat
    • Muscle cramps or pain
    • Numbness, tingling, pain, or weakness in the hands or feet rapid breathing sunken eyes
    • Thirst
    • Trembling, Weakness and Heaviness of the legs
    • Wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • Incidence not determined
    • Continuing ringing or buzzing or other unexplained noise in ears
    • Difficulty swallowing
    • Fear feeling of constant movement of self or surroundings
    • Feeling of fullness in the ears
    • General feeling of discomfort or illness
    • Hearing loss
    • Mild diarrhea
    • Sensation of spinning stomach
    • Soreness or Discomfort weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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