1 What is Elitek?

Brand: Elitek

Generic: Rasburicase injection

Elitek is used for the treatment of high uric acid blood levels (hyperuricemia) that may be induced by cancer drugs during cancer treatments.

This medicine is used in both adults and children with certain types of cancer such as leukemia, lymphoma, or solid tumors. This medicine is available only with your doctor's prescription in a medical facility.

2 What to Know Before Using

Before using Elitek, you must know all about the risks and complications associated with it. For this medicine, ensure that you inform your medical doctor whether you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

For non-prescription products, read the label or package ingredients carefully. Pediatric appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of rasburicase injection in children. Geriatric appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rasburicase injection in the elderly. In cases of pregnancy, pregnancies in animal studies have shown an adverse effect and there are no adequate studies in pregnant women or no animal studies have been conducted and there are no adequate studies in pregnant women.

Moreover, there are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. It is also known that certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine.

Make sure you tell your doctor if you have any other medical problems, such as : Blood problems that may include; hemolysis, methemoglobinemia, history of or Glucose-6-phosphate dehydrogenase (G6PD) deficiency which occurs as a hereditary metabolic disorder which affect the red blood cells. The use of this medicine in these patients is not recommended.

3 Proper Usage

The administration of Elitek can only be done by a trained health professional, so it will be used in a hospital or clinic. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so the needle will need to stay in place for up to 30 minutes.

4 Precautions to Take

In using Elitek, you must be careful and take some precautions as advised by your doctor.

Regular medical checkups for you and your child while under treatment and receiving this dose is important to ensure that the dose is working properly. This will also inform on whether one needs to continue using the medicine. Blood tests may be needed to check for unwanted effects. This medicine may cause a serious type of allergic reaction called anaphylaxis.

Anaphylaxis can be life-threatening and requires immediate medical attention. Inform your doctor right away if you or your child has a rash, itching, dizziness, lightheadedness, swelling of your hands, face, or mouth, trouble with breathing, or chest pain after you get the injection. Patients of African or Mediterranean ancestry are at higher risk of serious side effects and should be carefully evaluated by their doctor before starting this medicine. Check with your doctor right away if you or your child develops any of the following symptoms: bluish-colored lips, fingernails, or palms, dark urine, fever, headache, pale skin, rapid heart rate, shortness of breath, sore throat, or unusual bleeding or bruising after you receive this medicine.

5 Potential Side Effetcs

Side effects may occur in the cause of using Elitek and when they occur, medical attention will be required.

Check with your doctor or nurse immediately if any of the following side effects occur:

The most common side effects include:

  • Cracked lips diarrhea difficulty with swallowing sores
  • ulcers, or white spots on the lips, tongue, or inside the mouth

The less common side effects include:

  • Abdominal or stomach pain
  • Agitation
  • Black or red, tarry, stools
  • Bleeding gums
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • Changes in skin color
  • Changes in vision
  • Chest pain or discomfort chills
  • Coma
  • Confusion
  • Convulsions (seizures)
  • Cough
  • Coughing that sometimes produces a pink, frothy sputum
  • Coughing up blood
  • Decreased urination
  • Depression
  • Dilated
  • Neck veins
  • Dizziness
  • Dry mouth
  • Fainting fast, slow, or irregular heartbeat
  • Fever
  • Headache
  • Hostility
  • Increased menstrual flow or vaginal bleeding
  • Increased sweating
  • Increased thirst
  • Irritability
  • Itching, pain, redness, swelling, tenderness, or warmth on the skin
  • Lightheadedness
  • Lower back or side pain muscle
  • Twitching
  • Nausea
  • No blood pressure or pulse
  • Nosebleeds pain or discomfort in the arms, jaw, back, or neck pain, tenderness, or swelling of the foot or leg
  • Painful or difficult urination
  • Pains in the chest, groin, or legs, especially calves of the legs
  • Pale skin
  • Paralysis prolonged
  • Bleeding from cuts red or dark brown urine
  • Severe constipation
  • Severe headaches of sudden onset
  • Shortness of breath
  • Skin rash
  • Sneezing
  • Sore throat
  • Stopping of heart stupor
  • Sudden loss of coordination
  • Sudden onset of shortness of breath for no apparent reason
  • Sudden onset of slurred speech
  • Sunken eyes
  • Sweating
  • Swelling of the face, fingers, feet, or lower legs
  • Swollen glands
  • Temporary blindness
  • Thirst
  • Tightness in the chest
  • Troubled breathing
  • Unconsciousness
  • Unexplained or unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Vomiting
  • Weight gain
  • Wheezing
  • Wrinkled skin

Some of the rare side effects to occur in such like places include:

  • Back pain
  • Hives
  • Itching
  • Puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Yellow eyes or skin

Some of the side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common bothersome side effects include:

  • Bleeding
  • Blistering
  • Burning
  • Coldness
  • Discoloration of the skin
  • Feeling of pressure
  • Hives
  • Infection
  • Inflammation
  • Itching
  • Lumps
  • Numbness
  • Pain
  • Rash
  • Redness
  • Scarring
  • Soreness
  • Stinging
  • Swelling
  • Tenderness
  • Tingling
  • Ulceration, or warmth at the injection site burning
  • Crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • Feeling of warmth
  • Feeling unusually
  • Cold redness of the face, neck, arms, and occasionally, upper chest shivering

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

6 Related Clinical Trials