1 What is Entereg?

Brand: Entereg

Generic: Alvimopan

Entereg is a peripherally acting µ-opioid receptor antagonist which is usually used for the treatment of postoperative ileus and constipation following abdominal surgery. 

Administration of alvimopan orally before and after surgery hastens recovery of bowel function. It acts by blocking the effects of certain opioid receptors. 

In addition, it helps the stomach and bowel muscles to move properly. It is usually given to the patients in the hospital or under direct supervision of a health professional. 

Excessive use of this drug beyond the therapeutic dose and schedule may arise some undesirable effects, which often warrant immediate medical help.

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2 What to Know Before Using

Before using Entereg, you must know all about the risks and complications associated with it. Certain factors are responsible for any alteration of the drug action. 

Present and past illness, drug interactions, hypersensitivity reactions, pregnancy, lactation and metabolic impairments should be considered before you start this drug therapy.

There are certain medical conditions which may cause interactions with alvimopan, especially when you are suffering from chronic pain, liver and renal problems. 

If you have allergies to any particular drugs, you should tell your doctor. Additionally, history of pancreas and stomach surgery, suspected bowel blockade, pregnancy and lactation contradict the use of such medication.

You should not take medicines without prior consultation. You should give adequate information to the doctor about the drug therapy you are receiving. 

Some drugs should not be taken when you are prescribed alvimopan. For example, opioids (e.g. codeine) are avoided with alvimopan therapy. You should ask your health professional the list of drugs which should not be taken. 

3 Proper Usage

To use Entereg correctly, you must follow all instructions given by your doctor. The dose of this medicine will vary according to patient’s condition or requirements. 

You should follow the doctor's directions and advices.

The amount of medicine that you take must not exceed the maximum therapeutic dose. Also, the frequency of your daily drug administration and the duration of drug therapy depend on the particular medical problem for which you are taking the medicine.

Alvimopan is the drug which is orally given to the patients only in the hospital. Sometimes this drug is administered at home. You can take this drug with or without food. You should be confirmed about the dosage schedule of this drug.

 Always try to follow the directions given by your doctor. Administration of alvimopan is prescribed only for a short period of 7 days in those who have had bowel resection surgery. 

If you have any question concerning this medicine, you must ask the doctor. You are advised not take alvimopan more than15 doses or exceeding 7 days schedule. 

4 Precautions to Take

In using Entereg, you must be careful and take some precautions as advised by your doctor. You should not use any drug without a doctor’s prescription. Moreover, you should not use alvimopan if you are allergic. 

Some health problems including suspected bowel obstruction, liver and kidney diseases may be aggravated because of alvimopan. Administration of opioids is responsible for nausea, vomiting, abdominal pain, or loose motions in those who are receiving alvimopan. 

If you feel severe or persistent problems like these never delay to contact with your physician. You should have knowledge about the risk of side effects (e.g. diarrhea, abdominal cramps or pain) and the ways how to get rid of such problems. 

Some laboratory investigations including complete bood counts and potassium levels should be carried out during alvimopan therapy. These tests are usually recommended to monitor your health status in response to alvimopan. 

There are no well-controlled studies suggesting use of the drug safe in pregnancy and lactation. Potential benefits may warrant the use of alvimopan in pregnant women and during lactation but should be administered cautiously.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Entereg.

The health professional may give you the directions how to use this drug and the ways to prevent side effects arising from the drug therapy. 

Sometimes you may need to stop receiving such medicines in case of excessive undesirable effects. You should be aware of followings: 

In addition, an increased incidence of heart attacks are reported in patients who are receiving alvimopan compared to those not taking this drug for long-term use.