1 What is Epiduo?

Brand: Epiduo

Generic: Adapalene + Benzoyl Peroxide

Epiduo is a skin drug used for the treatment of acne vulgaris in patients 12 years of age and older. This drug is available as a gel containing adapalene 1 milligram in 1 gram and benzoyl peroxide 25 milligram in 1 gram.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also use this drug at the same time each day.

This drug is to be applied to the skin only. Avoid using it in the face, groin, or underarms, or for diaper rash, unless told so by your doctor.

First, wash and dry your hand before applying. The affected area should be cleansed and dried. The medication should be applied as a thin film to be gently rubbed in, as instructed by your doctor. Avoid covering or wrapping the treated area. Wash your hands after use. Avoid contact with eyes, mouth or mucous membranes. If contact occurs, rinse with plenty of water

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Epiduo may interact with medications such as:

  • Other drugs that may increase your sensitivity to sunlight (such as tetracyclines, thiazide water pills such as hydrochlorothiazide, sulfa drugs such as sulfamethoxazole, quinolone antibiotics such as ciprofloxacin), other acne skin treatments (such as tretinoin)
  • Hair perming solutions
  • Alcohol, lime or menthol-containing products such as astringents, toners, or shaving lotion
  • Medicated or abrasive soaps or cleansers
  • Soaps and cosmetics with a strong drying effect such as alpha hydroxy acids or glycolic acid
  • Products containing sulfur
  • Resorcinol
  • Salicylic acid

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to adapalene or benzoyl peroxide
  • Other skin conditions (such as eczema)
  • Pregnancy or lactation