1 What is Eryzole?

Brand: Eryzole, Pediazole

Generic: Erythromycin + Sulfisoxazole

Eryzole is used in the treatment of otitis media (ear inflammation and/ or infection) in children caused by the bacteria Haemophilus influenzae. This drug is available as a suspension containing erythromycin ethylsuccinate 200 milligram in 5 milliliter and sulfisoxazole acetyl 600 milligram in 5 milliliter.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Use a measuring spoon instead of an ordinary household spoon.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Erythromycin and Sulfisoxazolemay interact with medications such as:

  • Eletriptan
  • Ergot alkaloids such as ergotamine or dihydroergotamine
  • Methenamine
  • Ivabradine
  • Amiodarone
  • Dofetilide
  • Gatifloxacin
  • Moxifloxacin
  • Procainamide
  • Pimozide
  • Propafenone
  • Quinidine
  • Sotalol
  • Thioridazine
  • Colchicine
  • Certain diabetes medications such as glipizide, glyburide or tolbutamide
  • Digoxin
  • Live bacterial vaccines
  • Methotrexate
  • Oral PABA
  • Warfarin
  • Azole antifungals includingitraconazole and fluconazole
  • Rifamycins such as rifabutin
  • Quinupristin-dalfopristin
  • Calcium channel blockers such as diltiazem and verapamil
  • Certain anti-seizure medicines such as carbamazepine, phenytoin and valproate
  • Alfentanil
  • Bromocriptine
  • Buspirone
  • Benzodiazepines such as alprazolam, midazolam or triazolam
  • Caffeine-containing drugs
  • Cilostazol
  • Corticosteroids
  • Cyclosporine
  • Eplerenone
  • Erectile dysfunction medications such as sildenafil or vardenafil
  • Eszopiclone
  • Felodipine
  • Statins such as atorvastatin, lovastatin, or simvastatin
  • Quetiapine
  • Tacrolimus
  • Theophylline
  • Tolterodine
  • Vinblastine
  • Contraceptive pills, patches, or rings

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to erythromycin or sulfisoxazole or to other macrolide antibiotics such as azithromycin, clarithromycin
  • Allergy to sulfa medications
  • Severe allergies
  • Asthma
  • Blood and bone marrow disorders
  • Diabetes
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Kidney disease
  • Liver disease
  • Myasthenia gravis
  • Past medical history and family history of heart problems
  • Pregnancy or lactation