Evotaz

1 What is Evotaz?

Brand: Evotaz

Generic: Atazanavir and Cobicistat

Evotaz is used to treat infection caused by the human immunodeficiency virus.

This medicine does not cure HIV infection or AIDS. It interferes with the reproduction of HIV to slow down the destruction of the immune system. This will help to reduce your risk to develop complications associated with HIV infection.

Atazanavir and cobicistat combination will not keep you from transmitting HIV to other people. People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease.

This product is available in tablet.

2 What to Know Before Using

Before using Evotaz, you must know all about the risks and complications associated with it.

Tell to your doctor if you are allergic to atazanavir and cobicistat combination or to any other medications.

Safety and efficacy of this medication have not been established in children. This medicine is not recommended in infants younger than 3 months of age because atazanavir may cause kernicterus.

Although this medicine have not demonstrated geriatric-specific problems, older patients are more likely to have age-related liver, kidney, or heart problems, which may require caution in patients receiving atazanavir and cobicistat combination.

Pregnancy category B - No risks have been found in humans.

There are no adequate studies whether atazanavir and cobicistat combination can pass through breast milk or if it could cause harmful effects to the infant. Discuss with your doctor if you are breastfeeding a baby.

Taking this medication with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or change some of the other medicines you take.

  • Alfuzosin
  • Amifampridine
  • Bepridil
  • Carbamazepine
  • Cisapride
  • Colchicine
  • Conivaptan
  • Crizotinib
  • Dabrafenib
  • Dihydroergotamine
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Eletriptan
  • Eliglustat
  • Enzalutamide
  • Eplerenone
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Eszopiclone
  • Everolimus
  • Fentanyl
  • Flibanserin
  • Fluconazole
  • Fosphenytoin
  • Ibrutinib
  • Indinavir
  • Irinotecan
  • Irinotecan Liposome
  • Isavuconazonium Sulfate
  • Ivabradine
  • Ketoconazole
  • Lomitapide
  • Lovastatin
  • Lurasidone
  • Maraviroc
  • Mesoridazine
  • Methylergonovine
  • Methysergide
  • Midazolam
  • Mitotane
  • Naloxegol
  • Nelfinavir
  • Nevirapine
  • Pazopanib
  • Phenobarbital
  • Phenytoin
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Primidone
  • Quetiapine
  • Ranolazine
  • Rifampin
  • Rifapentine
  • Riociguat
  • Romidepsin
  • Sildenafil
  • Silodosin
  • Simvastatin
  • Sparfloxacin
  • St John's Wort
  • Suvorexant
  • Terfenadine
  • Thioridazine
  • Tolvaptan
  • Triazolam
  • Vemurafenib
  • Vinflunine
  • Vorapaxar
  • Ziprasidone

Taking this medicine with any of the following medications is usually not recommended, but with exception in some cases. Your doctor may change the dose or the frequency of one or both of your medicines if both medicines are prescribed together.

  • Ado-Trastuzumab Emtansine
  • Afatinib
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amlodipine
  • Amprenavir
  • Anagrelide
  • Apixaban
  • Aprepitant
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether
  • Atorvastatin
  • Avanafil
  • Axitinib
  • Bedaquiline
  • Boceprevir
  • Bosentan
  • Bosutinib
  • Brentuximab Vedotin
  • Brexpiprazole
  • Bromocriptine
  • Budesonide
  • Buprenorphine
  • Buserelin
  • Cabazitaxel
  • Cabozantinib
  • Cariprazine
  • Ceritinib
  • Cilostazol
  • Cimetidine
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Cobimetinib
  • Cyclophosphamide
  • Cyclosporine
  • Darunavir
  • Dasabuvir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Delavirdine
  • Deslorelin
  • Dexamethasone
  • Dexlansoprazole
  • Diazepam
  • Digoxin
  • Diltiazem
  • Disopyramide
  • Docetaxel
  • Domperidone
  • Donepezil
  • Eletriptan
  • Erlotinib
  • Erythromycin
  • Escitalopram
  • Esomeprazole
  • Etravirine
  • Everolimus
  • Famotidine
  • Felodipine
  • Flecainide
  • Fluoxetine
  • Fluticasone
  • Fluvastatin
  • Fosamprenavir
  • Garlic
  • Gonadorelin
  • Goserelin
  • Haloperidol
  • Histrelin
  • Hydrocodone
  • Hydroxychloroquine
  • Idelalisib
  • Ifosfamide
  • Iloperidone
  • Imatinib
  • Imipramine
  • Irinotecan
  • Irinotecan Liposome
  • Itraconazole
  • Ivacaftor
  • Ixabepilone
  • Ketoconazole
  • Lacosamide
  • Lamotrigine
  • Lansoprazole
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Levomilnacipran
  • Lidocaine
  • Lofepramine
  • Lopinavir
  • Lumefantrine
  • Macitentan
  • Metronidazole
  • Mexiletine
  • Mifepristone
  • Minocycline
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Nevirapine
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Nizatidine
  • Olaparib
  • Omeprazole
  • Ondansetron
  • Osimertinib
  • Oxcarbazepine
  • Oxycodone
  • Palbociclib
  • Panobinostat
  • Pantoprazole
  • Paritaprevir
  • Pasireotide
  • Piperaquine
  • Pixantrone
  • Ponatinib
  • Pravastatin
  • Propafenone
  • Quetiapine
  • Quinidine
  • Rabeprazole
  • Ranitidine
  • Regorafenib
  • Repaglinide
  • Retapamulin
  • Rifabutin
  • Rifapentine
  • Ritonavir
  • Rivaroxaban
  • Rosuvastatin
  • Ruxolitinib
  • Salmeterol
  • Saquinavir
  • Saxagliptin
  • Sevoflurane
  • Simeprevir
  • Sirolimus
  • Sonidegib
  • Sunitinib
  • Tacrolimus
  • Tadalafil
  • Tamoxifen
  • Tamsulosin
  • Telithromycin
  • Temsirolimus
  • Tenofovir Disoproxil Fumarate
  • Ticagrelor
  • Tipranavir
  • Topotecan
  • Toremifene
  • Trabectedin
  • Tramadol
  • Trazodone
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Venlafaxine
  • Verapamil
  • Vilanterol
  • Vilazodone
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Voriconazole
  • Warfarin

Taking this medicine with any of the following medications may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Your doctor may change the dose or how often you use one or both of the medicines if both medicines are prescribed together.

  • Atazanavir
  • Cobicistat
  • Dapsone
  • Darunavir
  • Desogestrel
  • Didanosine
  • Dienogest
  • Drospirenone
  • Efavirenz
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethynodiol Diacetate
  • Etonogestrel
  • Indinavir
  • Levonorgestrel
  • Lopinavir
  • Medroxyprogesterone Acetate
  • Mestranol
  • Methadone
  • Nelfinavir
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Telaprevir
  • Trazodone

Some medical conditions can interact with this medication. Tell your doctor if you have any of the following conditions:

  • Diabetes
  • Gallbladder problems
  • Hemophilia
  • Hyperglycemia
  • Fanconi syndrome
  • Renal failure
  • Liver disease
  • Heart block
  • Heart conduction problems
  • Kidney disease, severe— This medication is not recommended in these patients.
Have a question aboutHIV/AIDS Medicines?Ask a doctor now

3 Proper Usage

To use Evotaz correctly, you must follow all instructions given by your doctor. The dose of atazanavir and cobicistat combination varies for different patients.

If you are taking antacids or didanosine, you should take atazanavir and cobicistat combination 2 hours before or 1 hour after taking these medicines.

Recommended dosage of atazanavir and cobicistat combination tablets for HIV treatment:

  • Adults — One tablet once a day with food. Each tablet contains 300 milligrams of atazanavir and 150 mg of cobicistat.
  • Children — Use and dose must be determined by your doctor.

If you miss a dose of this medicine, take it as soon as possible. However, if it is near for your next dose, skip the missed dose and start again to your regular dosing schedule. Do not take a double dose to make up for a missed one.

Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of reach of children. Do not keep expired medications.

4 Precautions to Take

In using Evotaz, you must be careful and take some precautions as advised by your doctor.

Your doctor will be checking you regularly for the effectiveness of the medication. Blood tests may be ordered as well for undesirable effects.

Check with your doctor immediately or seek help immediately if:

  • If you or your child has symptoms of serious liver problem such as pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
  • If you or your child has blood in urine, nausea and vomiting, pain in the groin or genitals, or sharp back pain just below the ribs since this medication may increase your risk of having kidney stones.
  • If you notice changes in your blood sugar or urine test since this medication can affect your blood sugar levels.
  • If you noticed changes in your health.
  • If you or your child get dizzy or lightheaded since this medication may cause heart rhythm problems.
  • If you or your child have blistering, peeling, or loosening of the skin, chills, diarrhea, itching, joint or muscle pain, cough, red skin lesions, often with a purple center, skin rash, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness since serious skin reactions can occur with this medicine.
  • If you or your child notices changes in your body shape since this medication may cause you to have excess body fat.

Additional contraceptives are required because birth control pills may not work well while you are under atazanavir and cobicistat combination treatment.

This medicine will not keep you from transmitting HIV to other people during sex. It is recommended to understand and practice safe sex. It is also necessary to avoid re-using or sharing needles with other people.

Talk to your doctor if you are planning to take any other medication.

Do not use atazanavir if you are using the following medication:

  • Alfuzosin
  • Cisapride
  • Indinavir
  • Irinotecan
  • Lovastatin
  • Nevirapine
  • Oral midazolam
  • Pimozide
  • Rifampin
  • Salmeterol
  • Sildenafil
  • Simvastatin
  • Triazolam
  • Ergot medicines

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Evotaz.

Your doctor will be checking you regularly for the effectiveness of the medication. Blood tests may be ordered as well for undesirable effects.

Check with your doctor immediately or seek help immediately if:

  • you or your child has symptoms of serious liver problem such as pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
  • you or your child has blood in urine, nausea and vomiting, pain in the groin or genitals, or sharp back pain just below the ribs since this medication may increase your risk of having kidney stones.
  • you notice changes in your blood sugar or urine test since this medication can affect your blood sugar levels.
  • you noticed changes in your health.
  • you or your child get dizzy or lightheaded since this medication may cause heart rhythm problems.
  • you or your child have blistering, peeling, or loosening of the skin, chills, diarrhea, itching, joint or muscle pain, cough, red skin lesions, often with a purple center, skin rash, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness since serious skin reactions can occur with this medicine.
  • you or your child notices changes in your body shape since this medication may cause you to have excess body fat.

Additional contraceptives are required because birth control pills may not work well while you are under atazanavir and cobicistat combination treatment.

This medicine will not keep you from transmitting HIV to other people during sex. It is recommended to understand and practice safe sex. It is also necessary to avoid re-using or sharing needles with other people.

Talk to your doctor if you are planning to take any other medication.

Do not use atazanavir if you are using the following medication:

  • Alfuzosin
  • Cisapride
  • Indinavir
  • Irinotecan
  • Lovastatin
  • Nevirapine
  • Oral midazolam
  • Pimozide
  • Rifampin
  • Salmeterol
  • Sildenafil
  • Simvastatin
  • Triazolam
  • Ergot medicines
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