1 What is Factive?

Brand: Factive

Generic: Gemifloxacin

Factive is a Quinolone antibiotic used for the treatment of bronchitis and Pneumonia secondary to bacterial infections. This drug kills bacteria by inhibiting their DNA synthesis. This drug only works against bacteria and it is ineffective against viral infections.

This drug requires a prescription.

2 What to Know Before Using

Before using Factive, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children regarding the correlation of age to the effects of gemifloxacin have not been performed while safety and efficacy have not been established.

Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the usefulness of Gemifloxacin.

Adjustments in the dose of the elderly may be required since they are more likely to have age-related kidney or heart problems, or develop severe tendon problems.

Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate.

Harmful infant effects have been reported in studies of breastfeeding women. An alternative to this drug should be prescribed or you should stop breastfeeding while using this drug.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as:

  • Aluminum hydroxide
  • Calcium carbonate
  • Citalopram
  • Dicoumarol
  • Didanosine
  • Dofetilide
  • Fludrocortisone
  • Goserelin
  • Infliximab
  • Human insulin
  • Iron dextran
  • Ivabradine
  • Leuprolide
  • Magnesium oxide
  • Magnesium sulphate
  • Mifepristone
  • Mycophenolic acid,
  • Octreotide
  • Picosulfuric acid
  • Porfimer
  • Probenecid
  • Quinapril
  • Sevelamer
  • Strontium ranelate
  • Sucralfate
  • Varenicline
  • Verteporfin

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as:

3 Proper Usage

To use Factive correctly, you must follow all instructions exactly as directed by your healthcare professional. To prevent any side effects, take this drug exactly as directed in the label or as prescribed by your healthcare professional. You can take this drug with or without food.

It is recommended to swallow the tablet whole and avoid crushing, breaking, dissolving, or chewing it. It is recommended to increase fluid intake when taking this drug to prevent some unwanted effects of Gemifloxacin.

This drug works optimally when there is a maintained amount in the blood or urine. Take this drug at the same time each day. Avoid taking this drug alone with milk, yogurt, other dairy products, or any juice with calcium. It is okay to have dairy products or juice as part of a larger meal when you take this medicine.

Do not take this drug at the same time with:

  • Aluminium or Magnesium-containing antacids
  • Iron supplements
  • Multivitamins
  • Didanosine (VidexВ®)
  • Sucralfate (CarafateВ®)
  • Zinc

It is recommended to take these drugs 3 hours before or 2 hours after taking Gemifloxacin, since these drugs may keep Gemifloxacin from working properly. Take this drug for the full treatment time to ensure complete drug therapy and prevent any relapses.

The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

  • Adults with lung infections are given 320 milligrams of tablet once a day.
  • Use and dose in children must be determined by your healthcare professional.

A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light.

Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

In using Factive, you must be careful and take some precautions as advised by your doctor.

Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness and unwanted effects of the drug. Unwanted effects can be screened by blood and urine tests.

Contact your healthcare professional if your symptoms do not improve or if they become worse within a few days. Taking this drug with low serum potassium may increase your risk of having a:

Seek immediate medical attention if you experience symptoms of Anaphylaxis such as:

  • Itching, Hives, Hoarseness, Trouble breathing, Trouble swallowing, or any swelling of your hands, face, or mouth after you take this drug.

Consult with your healthcare professional if you experience serious side effects such as:

  • Black, Tarry stools
  • Blistering, Peeling, or Loosening of the skin
  • Bloody or Cloudy urine
  • Chills
  • Decreased urination
  • Diarrhea
  • Fever, Joint or Muscle pain
  • Red skin lesions, often with a purple center, sores, ulcer or white spots in the mouth or on the lips
  • Severe stomach pain
  • Skin rash, Swelling of the face, Fingers, Feet, and/or Lower legs
  • Unusual bleeding or bruising
  • Unusual weight gain

This drug may cause serious liver problems which can manifest as:

  • Nausea or Vomiting, Dark urine, Light-colored stools, Stomach pain, or Yellow eyes or skin

This drug may also cause diarrhea that may occur 2 months or more after you stop using this drug. Consult with your healthcare professional before you take any drug to treat diarrhea as these drugs may cause the diarrhea to worsen or make it last longer.

Inform your healthcare professional immediately if you experience symptoms of Peripheral neuropathy such as:

  • Numbness, Tingling, or Burning pain in your hands, arms, legs, or feet

This drug may rarely cause tendinitis or tearing of a tendon which can occur while you are taking the drug or after you finish taking it. This risk will increase if you are over 60 years of age, are using steroid drugs, have severe kidney problems, have a history of tendon problems, or if you have received an organ transplant.

Check with your healthcare professional immediately if you have sudden pain or swelling in a tendon after exercise, bruise more easily after an injury, or are unable to bear weight or move the affected area. It is recommended to avoid exercise until your healthcare professional clears you to do it.

This drug may increase your sensitivity to sunlight which may cause severe sunburn, skin rash, redness, itching, or discoloration. It is recommended to stay out of direct sunlight, especially between the hours of 10:00 A.M. and 3:00 P.M., and wear protective clothing and apply a sun block product that has a sun protection factor of at least 15.

This drug may cause dizziness, lightheadedness, drowsiness, or reduced alertness. Be careful in taking this drug before you drive, use machines, or do anything else that could be dangerous.

Consult with your healthcare professional before taking any other prescription or non-prescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Factive.

Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • Rash
  • Body aches or pain
  • Burning, Numbness, Tingling, or Painful sensations
  • Chest pain or tightness
  • Chills or Fever
  • Hives or Welts
  • Itching skin
  • Painful or Difficult urination
  • Shortness of breath
  • Sores, Ulcers or White spots on the lips or in the mouth
  • Swollen glands
  • Unsteadiness or Awkwardness
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Weakness in the arms, hands, legs, or feet
  • Yellow eyes or skin
  • Abdominal or stomach tenderness
  • Blistering, Peeling, or Loosening of the skin
  • Bloating or Swelling of the face, arms, hands, lower legs, or feet
  • Changes in urination
  • Changes in vision
  • Confusion
  • Diarrhea
  • Difficulty with breathing or swallowing
  • Difficulty with chewing or talking
  • Dizziness
  • Fast, Pounding, or Irregular heartbeat or pulse
  • Hives, Joint or Muscle pain
  • Muscle weakness
  • Nausea or Vomiting
  • Numbness or Tingling in the face, arms, or legs
  • Puffiness or Swelling of the eyelids or around the eyes, face, lips or tongue redness or other discoloration of the skin
  • Severe sunburn
  • Swelling of the face, fingers, or lower legs
  • Weight gain

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

Report any side effects to the FDA hotline at 1-800-FDA-1088.

6 Related Clinical Trials