Farydak

Farydak is a non-selective Histone deacetylase inhibitor used in combination with Bortezomib and Dexamethasone for the treatment of multiple Myeloma.

This drug requires a prescription.

Before using Farydak, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

• Studies in children regarding the correlation of age to the effects of panobinostat have not been performe while safety and efficacy have not been established.

• Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of panobinostat.

• Adjustments in the dose of elderly patients may be required since they are more likely to have unwanted effects.

• Infant risk is still undetermined when using this drug during breastfeeding.

Discuss with your healthcare professional about potential risks and benefits of taking this drug while breastfeeding. Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as strong CYP3A inducers such as:

• star fruit
• pomegranate or pomegranate juice
• grapefruit or grapefruit juice

CYP2D6 substrates such as:

• Atomoxetine
• Metoprolol
• Venlafaxine
• Thioridazine
• Pimozide

Antiarrhythmics such as:

• Amiodarone
• Disopyramide
• Procainamide

drugs that prolong the QT interval such as:

• Chloroquine
• Halofantrine
• Clarithromycin

or Antiemetic drugs that have known QT prolonging risk such as:

• Dolasetron
• Ondansetron
• Tropisetron

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as:

• anemia
• bleeding problem
• diarrhea
• electrolyte imbalance
• heart disease
• heart rhythm problems
• liver disease
• neutropenia
• thrombocytopenia
• angina
• infections

To use Farydak correctly, you must follow all instructions directed in the label or as prescribed by your healthcare professional. Cancer drugs are very strong and can have many side effects.

Discuss with your healthcare professional about the risks and benefits of taking this drug.

Take this drug at the same time each day, with or without food. Swallow the capsule whole with a cup of water and do not open, crush, break, or chew it.

Wash your skin with soap and clear water if you make accidental contact with broken or crushed capsules. Immediately rinse your eyes with water if accidental contact happens.

It is not recommended to eat grapefruit, star fruit, or pomegranate and drink grapefruit or pomegranate juice while using this drug. Do not take another capsule if you vomit after taking a dose. The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed.

The dosage of this drug you take depends on the medical problem for which you are using this drug. 

• Adults with multiple myeloma in combination with Bortezomib and Dexamethasone are initially given 20 milligrams once every other day for 3 doses per week of weeks 1 and 2 of each 21-day cycle for 8 cycles. Your healthcare professional may want you to continue treatment for an additional 8 cycles for a total of 16 cycles.

• Use and dose in children must be determined by your healthcare professional.

A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light.

Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

In using Farydak, you must be careful and take some precautions as advised by your doctor.

Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness and unwanted effects of the drug. Unwanted effects can be screened by blood tests.

This drug has Teratogenic potential and it is recommended to use an effective form of birth control to prevent any pregnancy from happening during therapy and for 1 month after the last dose of women and for 3 months after the last dose of men.

Inform your healthcare professional immediately if you think you have become pregnant while taking this drug.

This drug can cause diarrhea, nausea, or vomiting in most people, sometimes even after receiving drugs to prevent it. Ask your healthcare professional or nurse about other ways to control these side effects.

Contact your healthcare professional immediately if you have any changes to your heart rhythm which can manifest as feeling dizzy or faint, or fast, pounding, or uneven heartbeat.

Inform your healthcare professional you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

This drug may cause leukopenia which can increase your chance of getting an infection. It is recommended to avoid people with infections.

Consult with your healthcare professional immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Touching your eyes or the inside of your nose without proper hand washing is not recommended.

Be cautious in using sharp objects such as a safety razor or fingernail or toenail cutters to prevent any unnecessary wounds. It is recommended to avoid contact sports or other situations where bruising or injury could occur. Inform your healthcare professional if you have any kind of infection before you start using this drug.

Also tell your healthcare professional if you have ever had an infection that would not go away or an infection that kept coming back.

Check with your healthcare professional immediately if you have symptoms of a liver problem such as:

• pain or tenderness in the upper stomach
• pale stools
• dark urine
• loss of appetite
• nausea
• vomiting
• or yellow eyes or skin.

Consult with your healthcare professional before taking any other prescription or non-prescription drugs, and herbal or vitamin supplements.

As with many medications, there are several potential side effects associated with Farydak.

Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

• abdominal or stomach pain or tenderness
• black, tarry stools
• bloating or swelling of the face, arms, hands, lower legs, or feet
• clay colored stools
• confusion
• cough or sore throat
• dark or bloody urine
• decreased appetite
• decreased frequency or amount of urine
• dizziness, faintness, or lightheadedness especially when getting up suddenly from a lying or sitting position
• fast, irregular, pounding, or racing heartbeat or pulse
• fever, chills, or sweating
• headache
• increased thirst
• itching or skin rash
• loss of appetite
• lower back or side pain
• muscle spasms or twitching
• nausea or vomiting
• nervousness
• painful or difficult urination
• pinpoint red spots on the skin
• pounding in the ears
• rapid breathing
• seizures
• severe diarrhea
• slow or fast heartbeat
• swelling of the face, fingers, feet, or lower legs
• tingling of the hands or feet
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss
• yellow eyes or skin
• chest pain or discomfort
• coughing up blood
• difficulty with swallowing
• increased menstrual flow or vaginal bleeding
• nosebleeds
• pain in the shoulders, arms, jaw, or neck
• paralysis

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear.

Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

Report any side effects to the FDA hotline at 1-800-FDA-1088.